Table 6 15 miRNAs and target genes in the cancer-related canonical pathways
From: Modeling microRNA-mRNA Interactions Using PLS Regression in Human Colon Cancer
Cancer related canonical pathway | PLS predicted Target genes in the respective pathways | The nos. of cancer related miRNAs associated with the mRNA targets |
|---|---|---|
Protein Ubiquitination Pathway | PSMA3, PSMB2, PSMB4, PSMC2, PSMC4, PSMD8, UBE2I, USP22(8) | 14 |
Polyamine Regulation in Colon Cancer | OAZ1, ODC1, PSMA3, PSMB2, PSMB4, PSMC2, PSMC4, PSMD8(8) | 15 |
Purine Metabolism | ATP6V0B, GUK1, ITPA, POLR2H, PSMC2, PSMC4 (6) | 11 |
Circadian Rhythm Signaling | BHLHE40(1) | 2 |
Hypoxia Signaling in the Cardiovascular System | UBE2I(1) | 4 |
Cdc42 Signaling | ARPC1B, CDC42SE1(2) | 4 |
Pyrimidine Metabolism | ITPA, POLR2H (2) | 7 |
mTOR Signaling | DDIT4, EIF3B (2) | 7 |
NRF2-mediated Oxidative Stress Response | FTL, GSTP1, PPIB(3) | 7 |
Xenobiotic Metabolism Signaling | FTL, GSTP1(2) | 7 |