Distinctions in gastric cancer gene expression signatures derived from laser capture microdissection versushistologic macrodissection

Table 5 Gastric cancer genes in the literature that were differentially expressed between 20 cancer and 6 normal samples at feature selection P < 0.05 according to microarray data generated using each tissue processing method

Overexpressed genes in cancer			Underexpressed genes in cancer
LCM&Macro¹	LCM	Macro	LCM&Macro	LCM²	Macro
APOE	EGFR	AKT1	ANXA10	ANXA7	CDKN2B
AURKA	HGF	ANXA2	CASP6	BAD	FHIT
CCNE1	MET	CALR	CASP7	HLA-B
CDC20	RHOA	CCNB1	CDH1	HLA-E
CDC25B	TNS4	EEF2	CTNNA1	HLA-G
CXCR4		ESM1	GSN	PRSS8
E2F1		HIF1A	HLA-F	PTEN
EGR1		MINA	IQGAP2	SDHB
GRB2		PHB	KCNE2	SH3GLB1
HK2			KLF4	TFF1
ICAM1			MUC6
INHBA			RARB
LOXL2			SMAD4
MCM3
PTMA
SPARC

¹Previously reported overexpressed proteins for gastric cancer which were also overexpressed in our microdissected (LCM) and macrodissected cancer samples as compared with normal samples
²Previoulsy reported underexpressed proteins for gastric cancer which were also underexpressed in our microdissected (LCM) cancer samples, but not in macrodissected cancer samples

ISSN: 1755-8794