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Table 4 Genes that have a cohort-dependent association (P-value < 0.05) with the lifetime glioblastoma survival

From: Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival

Gene Symbol Probe Identifier Clinical Cohort P-value Level of Clinical Cohort Hazard Ratio1 Relevant literature references
Prkcb 2 207957_s_at Gender <.0001 Male 0.36 (0.24-0.55) [28]G
     Female 1.27 (0.84-1.93)  
   Therapy 0.0006 None 0.38 (0.25-0.60)  
     CRnoT 0.51 (0.36-0.73)  
     R 0.64 (0.46-0.88)  
     CRT 0.71 (0.44-1.13)  
     Other 0.75 (0.43-1.32)  
Sox10 209843_s_at Race 0.0018 White 0.55 (0.44-0.68) [10]G
     Other 1.08 (0.72-1.62)  
Egfr 211607_x_at Gender <.0001 Male 0.60 (0.50-0.72) [24]G
     Female 0.88 (0.74-1.04)  
Chi3l1 209396_s_at Therapy 0.0006 CRT 1.27 (0.96-1.70) [70]G
     R 1.28 (1.07-1.52)  
     Other 1.31 (1.04-1.66)  
     CRnoT 1.53 (1.31-1.79)  
     None 2.42 (1.56-3.75)  
C2 203052_at Gender 0.0033 Female 1.30 (1.03-1.65) n/a
     Male 1.93 (1.56-2.39)  
Prkcb 209685_s_at Gender <.0001 Female 1.31 (0.79-2.14) [28]G
     Male 5.21 (3.16-8.61)  
  1. n/a, No association with any type of cancer found in literature;
  2. 1 Hazard ratio estimate (95% confidence interval);
  3. 2 Interaction with a single clinical cohort factor;
  4. G Gene confirmed in an independent glioblastoma multiforme study; the number between square brackets denotes the corresponding literature reference;
  5. O Gene confirmed in an independent study on any other type of cancer; the number between square brackets denotes the corresponding literature reference.