Skip to main content

Table 4 Genes that have a cohort-dependent association (P-value < 0.05) with the lifetime glioblastoma survival

From: Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival

Gene Symbol

Probe Identifier

Clinical Cohort

P-value

Level of Clinical Cohort

Hazard Ratio1

Relevant literature references

Prkcb 2

207957_s_at

Gender

<.0001

Male

0.36 (0.24-0.55)

[28]G

    

Female

1.27 (0.84-1.93)

 
  

Therapy

0.0006

None

0.38 (0.25-0.60)

 
    

CRnoT

0.51 (0.36-0.73)

 
    

R

0.64 (0.46-0.88)

 
    

CRT

0.71 (0.44-1.13)

 
    

Other

0.75 (0.43-1.32)

 

Sox10

209843_s_at

Race

0.0018

White

0.55 (0.44-0.68)

[10]G

    

Other

1.08 (0.72-1.62)

 

Egfr

211607_x_at

Gender

<.0001

Male

0.60 (0.50-0.72)

[24]G

    

Female

0.88 (0.74-1.04)

 

Chi3l1

209396_s_at

Therapy

0.0006

CRT

1.27 (0.96-1.70)

[70]G

    

R

1.28 (1.07-1.52)

 
    

Other

1.31 (1.04-1.66)

 
    

CRnoT

1.53 (1.31-1.79)

 
    

None

2.42 (1.56-3.75)

 

C2

203052_at

Gender

0.0033

Female

1.30 (1.03-1.65)

n/a

    

Male

1.93 (1.56-2.39)

 

Prkcb

209685_s_at

Gender

<.0001

Female

1.31 (0.79-2.14)

[28]G

    

Male

5.21 (3.16-8.61)

 
  1. n/a, No association with any type of cancer found in literature;
  2. 1 Hazard ratio estimate (95% confidence interval);
  3. 2 Interaction with a single clinical cohort factor;
  4. G Gene confirmed in an independent glioblastoma multiforme study; the number between square brackets denotes the corresponding literature reference;
  5. O Gene confirmed in an independent study on any other type of cancer; the number between square brackets denotes the corresponding literature reference.