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Table 5 Genes that have a general association (P-value < 0.05) with the overall glioblastoma survival

From: Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival

Gene Symbol Probe Identifier P-value Hazard Ratio1 Relevant literature references
Tgfa 205015_s_at 0.0002 0.12 (0.04-0.37) [28]G
Sirpa 202895_s_at <.0001 0.24 (0.14-0.41) [26]G
Ctbp2 210835_s_at <.0001 0.28 (0.16-0.48) [101]O
Eef1e1 213907_at <.0001 0.37 (0.23-0.61) [102]O
Mapk3 212046_x_at 0.0041 0.43 (0.24-0.76) [103]O
Actr2 200727_s_at <.0001 0.43 (0.29-0.63) [24]G
Igh@ 211637_x_at 0.0167 0.44 (0.23-0.86) n/a
Plcg1 216551_x_at <.0001 0.46 (0.31-0.68) [26]G
Mgat3 209764_at <.0001 0.51 (0.37-0.71) [26]G
Lrp10 201412_at 0.0041 0.60 (0.42-0.85) [24]G
Idh1 201193_at 0.0051 0.60 (0.42-0.86) [24]G
Tmem8b 207839_s_at <.0001 0.60 (0.46-0.77) n/a
Ccna2 203418_at <.0001 0.60 (0.49-0.75) [104]O
Topors 204071_s_at 0.0007 0.61 (0.46-0.81) [26]G
Rpl37a 213459_at 0.0164 0.66 (0.47-0.93) [90]G
Mdm2 217373_x_at <.0001 0.69 (0.61-0.78) [26]G
E2f3 203693_s_at 0.06722 0.75 (0.55-1.02) [28]G
Mdfic 211675_s_at 0.0006 0.78 (0.68-0.90) [105]O
Sod2 215078_at <.0001 0.80 (0.73-0.88) [25]G
Akr1c3 209160_at 0.0014 0.83 (0.73-0.93) [26]G
Thbs4 204776_at 0.0007 1.18 (1.07-1.30) [106]O
Shc3 206330_s_at 0.0031 1.32 (1.10-1.59) [28]G
Pik3r1 212249_at 0.0145 1.34 (1.06-1.69) [20]G
Nkx2-5 206578_at 0.0027 1.38 (1.12-1.70) [107]O
Hras 212983_at 0.0187 1.42 (1.06-1.90) [85]G
Bhlhb9 213709_at 0.0192 1.42 (1.06-1.92) [108]O
C9orf95 219147_s_at 0.0004 1.43 (1.17-1.73) [109]O
C17orf101 219254_at 0.0085 1.46 (1.10-1.94) [110]O
Nol3 59625_at <.0001 1.46 (1.21-1.76) [111]O
Rangap1 212125_at 0.0225 1.47 (1.06-2.05) [26]G
Ftsj2 222130_s_at 0.017 1.48 (1.07-2.05) [112]O
Rrm1 201476_s_at 0.0006 1.49 (1.19-1.87) [27]G
Jag2 209784_s_at 0.0351 1.63 (1.03-2.57) [24]G
Tnpo1 212635_at 0.0054 1.89 (1.20-2.96) n/a
Myo7a 211103_at 0.0033 1.97 (1.25-3.10) [113]O
Actr2 200729_s_at 0.0001 2.18 (1.47-3.23) [24]G
Csf1 209716_at <.0001 2.33 (1.65-3.27) [26]G
Ank1 208352_x_at 0.0003 2.38 (1.49-3.82) [24]G
B3galnt1 211379_x_at <.0001 2.40 (1.76-3.28) [114]O
Kras 214352_s_at 0.002 2.44 (1.38-4.31) [85]G
Ewsr1 210012_s_at 0.0005 2.49 (1.49-4.15) [26]G
Sec24c 202361_at <.0001 2.84 (1.76-4.60) n/a
Rpl10l 217559_at <.0001 2.95 (1.83-4.74) [115]O
Ighg1 211908_x_at 0.0007 3.41 (1.68-6.93) [116]O
Ighg1 211693_at 0.0007 4.33 (1.86-10.04) [116]O
  1. n/a, No association with any type of cancer found in literature;
  2. 1 Hazard ratio estimate (95% confidence interval);
  3. 2 Borderline significant (P-value < 0.1) included for completeness;
  4. G Gene confirmed in an independent glioblastoma multiforme study; the number between square brackets denotes the corresponding literature reference;
  5. O Gene confirmed in an independent study on any other type of cancer; the number between square brackets denotes the corresponding literature reference.