Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival

Table 8 Genes that have a cohort-dependent association (P-value < 0.05) with progression-free glioblastoma survival

Gene Symbol	Probe Identifier	Clinical Cohort	P-value	Level of Clinical Cohort	Hazard Ratio¹	Relevant literature references
Gdf10	206159_at	Gender	0.0317	Male	0.37 (0.23-0.60)	n/a
				Female	0.80 (0.45-1.42)
Vav3	218807_at	Race	0.008	Other	0.41 (0.29-0.59)	[81]^G
				White	0.68 (0.55-0.85)
Rps20	216246_at	Race	0.0003	Other	0.75 (0.39-1.44)	[75]^O
				White	1.83 (1.03-3.24)
Rab31	217764_s_at	Race	<.0001	White	1.47 (0.93-2.30)	[74]^O
				Other	7.72 (3.71-16.07)
Apool	213289_at	Therapy	0.0026	R	1.64 (1.13-2.38)	[131]^O
				None	1.93 (0.63-5.98)
				CRnoT	2.23 (1.55-3.20)
				Other	3.86 (1.83-8.13)
				CRT	4.82 (2.69-8.63)

n/a, No association with any type of cancer found in literature;
¹ Hazard ratio estimate (95% confidence interval);
^G Gene confirmed in an independent glioblastoma multiforme study; the number between square brackets denotes the corresponding literature reference
^O Gene confirmed in an independent study on any other type of cancer; the number between square brackets denotes the corresponding literature reference.

ISSN: 1755-8794