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Figure 2 | BMC Medical Genomics

Figure 2

From: A genome-wide DNA methylation study in colorectal carcinoma

Figure 2

Overlap of results from different normalization methods. Venn diagram showing overlap between the lists of differentially methylated autosomal loci identified by ANOVA models from four different normalization procedures- (a) no normalization of signal intensity, no normalization of β-values- right lower ellipse (n = 724) (b) no normalization of signal intensity to calculate β-values initially, but subsequently quantile normalization of β-values- right upper ellipse (n = 632); (c) background normalization of signal intensity to calculate β-values, but no normalization of β-values- left upper ellipse (n = 852) and (d) background normalization of signal intensity to calculate β-values, and quantile normalization of β-values- left lower ellipse (n = 759).

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