Figure 4

Heatmap of 20 highly differentially methylated loci. Unsupervised hierarchical clustering of 20 DML (rows) in 48 samples (columns) that are shown in Figure 3. These 20 DML represent the most highly differentially methylated loci (Δ β ≤ -0.45 or ≥ 0.45 with FDR 0.01) and/or whose variation could be explained by tissue type (at least 65%) in our ANOVA models. Location of the tumor (proximal or distal colon) and the differentiation of the tumor (moderately differentiated or poorly differentiated) are shown above the heatmap.