A Overlap of hypermethylation, down-regulation and differential copy number state. B: Overlap of hypomethylation, up-regulation and differential copy number state. C: Heatmap of differentially expressed genes: Hierarchical clustering of the gene expression data from the 25 hypermethylated genes (rows) shown in Figure 9A across the samples (columns). These genes do not overlap with regions showing significantly different copy number state in CRC tissue. The clusters generated (top dendogram) in this analysis separated most of the CRC tissues from the normal colonic mucosa tissues.