A genome-wide DNA methylation study in colorectal carcinoma

BMC Medical Genomics

Table 1 Results from two-level nested cross-validation

No. of variables in KNN model	Expected test characteristics in another set of data
	Accuracy	SEN (%)	SPEC (%)	PPV (%)	NPV (%)
4 variables	94.44	91.67	95.83	95.65	92.00
6 variables	92.36	87.50	95.83	95.45	88.46
8 variables	92.36	87.50	95.83	95.45	88.46
10 variables	92.36	87.50	95.83	95.45	88.46
21 variables	93.05	89.58	95.83	95.56	90.20
31 variables	92.36	87.50	95.83	95.45	88.46
41 variables	92.36	89.58	95.83	95.56	90.20
51 variables	93.06	89.58	95.83	95.56	90.20

K-Nearest Neighborhood model with Euclidean distance measure & 3 neighbor was used; SEN: sensitivity; SPEC: specificity; PPV: Positive Predictive Value; NPV: Negative Predictive Value.

ISSN: 1755-8794