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Table 1 Cohorts for genetic studies

From: Genome wide association study identifies KCNMA1contributing to human obesity

     obese cases    lean and population-based controls
  Cohort SNP§ Nationality female/male BMI* (kg/m2) age* (years) female/male BMI* (kg/m2) age* (years)
Discovery 1 406,177 Swedish 131/33§ 44.7 ± 4.7 43.8 ± 12.6 137/26 22.2 ± 1.8 51.6 ± 6.1
Replication 2 700 Swedish 370/90§§ 44.6 ± 4.6 42.2 ± 13.2 206/41 22.6 ± 1.7 51.6 ± 5.3
Replication 3 21 Swedish 1025/789 37.1 ± 5.4 46.6 ± 11.4 819/885 22.8 ± 1.7 48.7 ± 10.8
Replication 4** 21 French 641/344 33.7 ± 8.2 14.1 ± 5.0 289/243# 18.7 ± 3.3 11.8 ± 1.6
Replication 5 2 French 682/246 48.5 ± 7.6 43.0 ± 12.1 1630/1108# 23.8 ± 3.5 49.7 ± 6.3
Replication 6** 2 German 278/209 33.4 ± 6.8 14.4 ± 3.7 271/171 18.3 ± 1.1 16.1 ± 5.8
Total     3127/1711    3353/2474   
  1. * Values are mean ± SD; ** Cohorts comprising children in which case BMI Z-scores were used to define obesity status as defined in Methods.
  2. § Number of SNPs genotyped in each cohort. The 700 most significantly obesity associated SNPs in the GWA were analyzed in cohort 2 (threshold P = 0.003). Subsequently, nominal association with obesity was used as threshold to determine whether a SNP would be followed up by genotyping additional cohorts. # population-based controls