Genome wide association study identifies KCNMA1contributing to human obesity

BMC Medical Genomics

Table 4 Association of SNPs with obesity under different genetic models

SNP	Gender	Genetic model	Obese (n)	Control (n)	OR (95% C.I.)	P value§§
rs2116830	All	Additive*	3267/1280/126	3060/1520/192	1.27 (1.13, 1.43)	4.2 ×10^-05
(KCNMA1)		Dominant**	4547/126	4580/192	1.51 (1.20, 1.89)	0.0004
		Recessive§	3267/1406	3060/1712	1.30 (1.19, 1.42)	2.5 × 10^-09
	Male	Additive	1127/475/48	1311/641/80	1.20 (1.00, 1.44)	0.055
		Dominant	1602/48	1952/80	1.37 (0.95, 1.97)	0.092
		Recessive	1127/523	1311/721	1.19 (1.03, 1.36)	0.016
	Female	Additive	2138/805/78	1747/879/111	1.32 (1.14, 1.53)	0.00024
		Dominant	2943/78	2626/111	1.60 (1.19, 2.14)	0.0019
		Recessive	2138/883	1747/990	1.37 (1.23, 1.53)	2.0 ×10^-08
rs988712	All	Additive	2952/1504/183	2662/1737/327	1.41 (1.28, 1.55)	1.1 ×10^-12
(BDNF)		Dominant	4456/183	4399/327	1.81 (1.50, 2.18)	3.7 × 10^-10
		Recessive	2952/1687	2662/2064	1.36 (1.25, 1.47)	6.2 × 10^-13
	Male	Additive	1041/519/82	1106/753/140	1.27 (1.10, 1.46)	0.0011
		Dominant	1560/82	1859/140	1.43 (1.08, 1.90)	0.012
		Recessive	1041/601	1106/893	1.40 (1.22, 1.60)	8.7 × 10^-07
	Female	Additive	1909/985/101	1554/983/187	1.51 (1.33, 1.71)	1.47 × 10^-10
		Dominant	2894/101	2537/187	2.11 (1.65, 2.71)	3.4 × 10^-09
		Recessive	1909/1086	1554/1170	1.32 (1.19, 1.47)	2.4 × 10^-07

* Numbers of subject with genotype GG, GT or TT, ** Numbers of subject with genotype GG or GT versus number of subjects with genotype TT, and § numbers of subject with genotype GG versus GT and T where G is the effect allele;
§§Model based analysis was carried out by logistic regression, se Statistical analysis.

ISSN: 1755-8794