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Table 4 Association of SNPs with obesity under different genetic models

From: Genome wide association study identifies KCNMA1contributing to human obesity

SNP Gender Genetic model Obese (n) Control (n) OR (95% C.I.) P value§§
rs2116830 All Additive* 3267/1280/126 3060/1520/192 1.27 (1.13, 1.43) 4.2 ×10-05
(KCNMA1)   Dominant** 4547/126 4580/192 1.51 (1.20, 1.89) 0.0004
   Recessive§ 3267/1406 3060/1712 1.30 (1.19, 1.42) 2.5 × 10-09
  Male Additive 1127/475/48 1311/641/80 1.20 (1.00, 1.44) 0.055
   Dominant 1602/48 1952/80 1.37 (0.95, 1.97) 0.092
   Recessive 1127/523 1311/721 1.19 (1.03, 1.36) 0.016
  Female Additive 2138/805/78 1747/879/111 1.32 (1.14, 1.53) 0.00024
   Dominant 2943/78 2626/111 1.60 (1.19, 2.14) 0.0019
   Recessive 2138/883 1747/990 1.37 (1.23, 1.53) 2.0 ×10-08
rs988712 All Additive 2952/1504/183 2662/1737/327 1.41 (1.28, 1.55) 1.1 ×10-12
(BDNF)   Dominant 4456/183 4399/327 1.81 (1.50, 2.18) 3.7 × 10-10
   Recessive 2952/1687 2662/2064 1.36 (1.25, 1.47) 6.2 × 10-13
  Male Additive 1041/519/82 1106/753/140 1.27 (1.10, 1.46) 0.0011
   Dominant 1560/82 1859/140 1.43 (1.08, 1.90) 0.012
   Recessive 1041/601 1106/893 1.40 (1.22, 1.60) 8.7 × 10-07
  Female Additive 1909/985/101 1554/983/187 1.51 (1.33, 1.71) 1.47 × 10-10
   Dominant 2894/101 2537/187 2.11 (1.65, 2.71) 3.4 × 10-09
   Recessive 1909/1086 1554/1170 1.32 (1.19, 1.47) 2.4 × 10-07
  1. * Numbers of subject with genotype GG, GT or TT, ** Numbers of subject with genotype GG or GT versus number of subjects with genotype TT, and § numbers of subject with genotype GG versus GT and T where G is the effect allele;
  2. §§Model based analysis was carried out by logistic regression, se Statistical analysis.