Graphical depiction of the gene clustering. The clustering of the 489 genes derived from their Euclidean distances in the Kamada-Kawai and gene maximum multiplicity three-dimensional space. The dissimilarity distance calculated in the Ward hierarchy ranges from 0.0 to 41.09. The dissimilarity threshold for the clusters is 5.07. The lower portion of the figure depicts cluster 4, which has the highest gene maximum multiplicity value of 10.3. The asterisks mark the known causal gene mutations within this cluster.