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Table 2 Table of the functional analysis made in KEGG for protein signature

From: A computational procedure for functional characterization of potential marker genes from molecular data: Alzheimer's as a case study

KEGG pathway

KEGG category

n.

P

Cytokine-cytokine receptor interaction

 

14

9.69e-26

Cell adhesion molecules (CAMs)

Signaling Molecules and Interaction

1

7.59e-2

Neuroactive ligand-receptor interaction

 

1

1.67e-1

Hematopoietic cell lineage

 

7

6.00e-14

Natural killer cell mediated cytotoxicity

 

4

9.12e-7

Toll-like receptor signaling pathway

Immune System

3

2.19e-5

Fc epsilon RI signaling pathway

 

2

1.01e-3

Leukocyte transendothelial migration

 

2

2.29e-3

T cell receptor signaling pathway

 

1

5.57e-2

Apoptosis

Cell Growth and Death

5

1.54e-9

MAPK signaling pathway

 

4

2.21e-5

Jak-STAT signaling pathway

Signal Transduction

4

1.90e-6

TGF-beta signaling pathway

 

1

4.96e-2

Adipocytokine signaling pathway

Endocrine System

3

1.13e-5

PPAR signaling pathway

 

1

4.17e-2

Epithelial cell signaling in Helicobacter pylori infection

Infectious Diseases

2

8.05e-4

Gap junction

Cell Communication

2

1.33e-3

Focal adhesion

 

2

6.43e-3

Glioma

Cancers

2

6.66e-4

Pancreatic cancer

 

1

4.42e-2

Type I diabetes mellitus

Metabolic Diseases

2

2.96e-4

Type II diabetes mellitus

 

2

3.26e-4

Regulation of actin cytoskeleton

Cell Motility

2

6.89e-3

  1. Enriched pathways of the protein signature resulting from the WebGestalt functional analysis with KEGG. For each pathway, the table reports the pathway name, its KEGG category, the number of selected genes (n.) and the p-value. The enriched pathways are displayed in boldface.