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Table 3 Datasets in which genes in common metastatic signature of metastasis are significant with a Q < 0.1

From: Meta-analysis of multiple microarray datasets reveals a common gene signature of metastasis in solid tumors

Genes differentially

expressed in metastasis

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

Num studies

Up - regulated genes

                   

EZH2

          

X

X

X

 

X

X

  

5

Down - regulated genes

                   

ACTG2

 

X

    

X

   

X

      

X

4

FUCA1

       

X

 

X

X

X

      

4

JUNB

        

X

 

X

X

   

X

  

4

PDE4D

 

X

      

X

 

X

    

X

  

4

RAP1A

 

X

      

X

 

X

     

X

 

4

SYNPO2

 

X

        

X

    

X

 

X

4

CASP7

 

X

    

X

   

X

      

X

4

GADD45B

        

X

X

 

X

   

X

  

4

KRT15

          

X

X

   

X

 

X

4

PIGB

       

X

 

X

X

      

X

4

RARRES1

 

X

      

X

 

X

X

      

4

TCF21

 

X

 

X

       

X

     

X

4

CSRP1

 

X

      

X

  

X

     

X

4

GJA1

       

X

X

X

X

       

4

LUM

 

X

   

X

 

X

  

X

       

4

PKIG

 

X

      

X

  

X

    

X

 

4

SELE

        

X

 

X

X

     

X

4

TMEM49

       

X

  

X

   

X

X

  

4

CYR61

        

X

X

X

X

      

4

GNG12

 

X

      

X

 

X

    

X

  

4

MAPK1

 

X

     

X

  

X

    

X

  

4

PLA2G2A

 

X

      

X

 

X

X

      

4

SLC12A4

       

X

   

X

   

X

 

X

4

TPM1

 

X

      

X

 

X

X

      

4

DPT

 

X

     

X

  

X

     

X

 

4

GSN

 

X

      

X

 

X

X

      

4

MFAP4

 

X

   

X

    

X

X

      

4

PLEKHC1

        

X

 

X

X

   

X

  

4

SMTN

 

X

      

X

  

X

    

X

 

4

TSC22D1

        

X

 

X

X

   

X

  

4

DSTN

       

X

X

 

X

X

      

4

IER2

 

X

      

X

  

X

   

X

  

4

NBL1

 

X

      

X

  

X

   

X

  

4

PPP1R12A

 

X

   

X

  

X

 

X

       

4

SORBS1

 

X

        

X

    

X

 

X

4

VCL

 

X

      

X

  

X

     

X

4

FILIP1L

 

X

      

X

 

X

X

      

4

ISL1

        

X

 

X

X

     

X

4

PAGE4

          

X

X

   

X

 

X

4

FLNC

 

X

        

X

X

     

X

4

JMJD3

 

X

      

X

  

X

   

X

  

4

PAM

       

X

X

 

X

    

X

  

4

FOSB

        

X

X

 

X

X

     

4

PCP4

          

X

X

   

X

 

X

4

ACTA2

       

X

X

 

X

X

   

X

  

5

CNN1

 

X

     

X

  

X

X

     

X

5

DMN

 

X

         

X

 

X

 

X

 

X

5

HBEGF

 

X

     

X

X

X

X

       

5

MGP

        

X

 

X

X

   

X

 

X

5

PYRO1D1

 

X

      

X

 

X

X

    

X

 

5

TACC1

 

X

   

X

  

X

 

X

    

X

  

5

BMPR1A

 

X

      

X

 

X

X

     

X

5

CTGF

       

X

X

X

X

X

      

5

FBLN1

 

X

     

X

X

 

X

X

      

5

KCNMA1

 

X

     

X

   

X

  

X

X

  

5

NR4A1

 

X

      

X

  

X

X

  

X

  

5

RBPMS

        

X

X

X

X

    

X

 

5

TAGLN

        

X

 

X

X

   

X

 

X

5

CAMK2G

 

X

      

X

X

 

X

   

X

  

5

DIO2

 

X

       

X

X

X

     

X

5

FHL1

 

X

      

X

X

X

X

      

5

LMOD1

 

X

        

X

X

   

X

 

X

5

NR4A3

       

X

X

X

 

X

   

X

  

5

SPARCL1

 

X

      

X

 

X

X

  

X

   

5

ZFP36

        

X

X

X

X

   

X

  

5

CCND2

 

X

      

X

 

X

X

   

X

  

5

DKFZP564O0823

 

X

      

X

 

X

X

     

X

5

FXYD3

 

X

 

X

     

X

X

X

      

5

MCL1

        

X

 

X

X

   

X

X

 

5

PPP1R12B

 

X

      

X

 

X

X

     

X

5

SPG20

        

X

X

X

X

  

X

   

5

BTG2

 

X

      

X

X

X

X

   

X

  

6

JUND

 

X

     

X

X

X

 

X

   

X

  

6

KCNMB1

 

X

      

X

 

X

X

   

X

 

X

6

MYH11

 

X

      

X

 

X

X

   

X

 

X

6

MYLK

 

X

      

X

 

X

X

   

X

 

X

6

SOD3

 

X

      

X

X

 

X

    

X

X

6

TPM2

 

X

      

X

 

X

X

 

X

X

X

 

X

8

  1. The studies in which each gene is differentially expressed are given as an × under the study number, as given in Table 1. "Num studies" refers to the total number of studies in which the gene is significantly differentially expressed with a Q-value < 0.1.
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BMC Medical Genomics

ISSN: 1755-8794

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