Figure 4

Status of RAS and MYC pathway activities in paired fresh-frozen and FFPE xenografts. (A) Heatmaps representing the expression levels of genes comprising the gene expression signature that differentiates between HMECs infected with adenovirus expressing GFP (control) versus HMECs infected with adenovirus expressing RAS or MYC as indicated. Within the heatmap, columns represent samples and rows represent genes, with expression values on a low to high continuum represented by a blue to red continuum, respectively. (B) Scatterplot of the fresh-frozen xenografts (X-axis) versus the FFPE xenografts (Y-axis) for the RAS pathway (top) or MYC pathway (bottom). The simple linear regression model and p-value is drawn for each Pearson correlation.