Table 3 Gene Ontology enrichment analysis for creQTL at q = 0.05.

7214

18

gamma-aminobutyric acid signaling pathway

< 0.008

7612

21

learning

< 0.008

7411

62

axon guidance

< 0.008

7156

69

homophilic cell adhesion

< 0.008

7417

80

central nervous system development

< 0.008

7155

320

cell adhesion

< 0.008

45944

203

positive regulation of transcription from RNA polymerase II promoter

0.008

7399

225

nervous system development

0.008

45595

12

regulation of cell differentiation

0.014

48754

19

branching morphogenesis of a tube

0.018

30900

42

forebrain development

0.018

45165

29

cell fate commitment

0.027

43065

69

positive regulation of apoptosis

0.04

7224

16

smoothened signaling pathway

0.043

7420

74

brain development

0.043

30326

35

embryonic limb morphogenesis

0.043

7169

56

transmembrane receptor protein tyrosine kinase signaling pathway

0.043

6813

94

potassium ion transport

0.043

Category ID

Category Size

Category Title

q _KS

5913

18

cell-cell adherens junction

< 0.004

45202

156

synapse

< 0.004

30054

231

cell junction

< 0.004

14069

49

postsynaptic density

0.004

45211

79

postsynaptic membrane

0.004

30424

83

axon

0.006

781

13

chromosome, telomeric region

0.013

5912

27

adherens junction

0.013

34707

36

chloride channel complex

0.016

5923

40

tight junction

0.016

5886

1504

plasma membrane

0.037

42734

21

presynaptic membrane

0.038

5578

174

proteinaceous extracellular matrix

0.038

Category ID

Category Size

Category Title

q _KS

8066

11

glutamate receptor activity

< 0.008

5216

187

ion channel activity

< 0.008

5509

491

calcium ion binding

< 0.008

4993

11

serotonin receptor activity

< 0.008

4970

12

ionotropic glutamate receptor activity

0.009

5234

12

extracellular-glutamate-gated ion channel activity

0.009

43565

273

sequence-specific DNA binding

0.009

5244

85

voltage-gated ion channel activity

0.016

4890

17

GABA-A receptor activity

0.017

5246

11

calcium channel regulator activity

0.019

31404

49

chloride ion binding

0.023

30594

18

neurotransmitter receptor activity

0.028

30165

32

PDZ domain binding

0.029

5001

13

transmembrane receptor protein tyrosine phosphatase activity

0.029

5267

53

potassium channel activity

0.029

5230

24

extracellular ligand-gated ion channel activity

0.037

5254

48

chloride channel activity

0.041

8146

26

sulfotransferase activity

0.041

16455

11

RNA polymerase II transcription mediator activity

0.042