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Table 1 Summary of the four networks

From: Integrative network analysis identifies key genes and pathways in the progression of hepatitis C virus induced hepatocellular carcinoma

Network

#Genes

#Interactions

#DEGs*

#Hub interactions†

Hub gene‡

Normal to cirrhosis

55

67

53 (96.3%)

42 (62.7%)

LCK, CD44, CD74, COL1A2, MMP2, VCAN, STAT1, COL1A1

Cirrhosis to dysplasia

38

50

37 (97.4%)

35 (70.0%)

LCK, CD44, MMP9, COL1A1, PTPRC, MMP2, TGFB1

Dysplasia to early HCC

60

65

53 (88.3%)

37 (56.9%)

CDC2, MAD2L1, PRKCA, CDC20, NDC80, UBQLN4

Early to advanced HCC

68

98

59 (86.8%)

79 (80.6%)

CDC2, NDC80, PLK1, MCM2, AURKB, CCNA2, CDC20, AURKA, CCNB1, NUF2, MMP9

  1. *Differentially expressed genes (DEGs) were defined as genes with fold change ≥ 2 or ≤ 0.5 and student t test P value ≤ 0.01.
  2. †Hub interactions refer to the total number of interactions involving hub genes.
  3. ‡Hub genes were defined to have at least 5 interactions in each network.
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BMC Medical Genomics

ISSN: 1755-8794

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