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Table 1 Summary of the four networks

From: Integrative network analysis identifies key genes and pathways in the progression of hepatitis C virus induced hepatocellular carcinoma

Network #Genes #Interactions #DEGs* #Hub interactions Hub gene
Normal to cirrhosis 55 67 53 (96.3%) 42 (62.7%) LCK, CD44, CD74, COL1A2, MMP2, VCAN, STAT1, COL1A1
Cirrhosis to dysplasia 38 50 37 (97.4%) 35 (70.0%) LCK, CD44, MMP9, COL1A1, PTPRC, MMP2, TGFB1
Dysplasia to early HCC 60 65 53 (88.3%) 37 (56.9%) CDC2, MAD2L1, PRKCA, CDC20, NDC80, UBQLN4
Early to advanced HCC 68 98 59 (86.8%) 79 (80.6%) CDC2, NDC80, PLK1, MCM2, AURKB, CCNA2, CDC20, AURKA, CCNB1, NUF2, MMP9
  1. *Differentially expressed genes (DEGs) were defined as genes with fold change ≥ 2 or ≤ 0.5 and student t test P value ≤ 0.01.
  2. Hub interactions refer to the total number of interactions involving hub genes.
  3. Hub genes were defined to have at least 5 interactions in each network.