Table 3 Pathways that contain significant SNPs (p < 10-3) inferred from both AGS and TCGA samples
PATHWAY* | AGS_SNP | GENE | TCGA_SNP | GENE |
|---|---|---|---|---|
Purine metabolism (p = 3.50E-04)** | Â | Â | Â | Â |
Small cell lung cancer (p = 4.35E-04) ** | Â | Â | Â | Â |
Non-small cell lung cancer (p = 2.6E-04) ** | rs7617530 | FHIT | rs13059601 | FHIT |
Neuroactive ligand-receptor interaction (p = 8.00E-04) ** | rs1011455 | GABRG3 | Â | Â |
| Â | rs4887546 | GABRG3 | Â | Â |
| Â | rs1011456 | GABRG3 | rs12904325 | GABRG3 |
Vascular smooth muscle contraction (p = 3.48E-04) ** | Â | Â | Â | Â |
Gap junction (p = 1.30E-04) ** | rs4400745 | PRKG1 | Â | Â |
Long-term depression (p = 6.95E-04) ** | Â | Â | Â | Â |
Olfactory transduction (p = 3.47E-04) ** | rs4466778 | PRKG1 | rs1922139 | PRKG1 |
Axon guidance (p = 3.91E-04) ** | Â | Â | rs11082983 | DCC |
Pathways in cancer (p = 2.13E-03) | Â | Â | rs11872471 | DCC |
Colorectal cancer (p = 8.69E-05) ** | rs1145245 | DCC | rs12604940 | DCC |
Focal adhesion (p = 1.95E-03) | Â | Â | Â | Â |
ECM-receptor interaction (p = 8.69E-04) ** | Â | Â | Â | Â |
Cell adhesion molecules (CAMs) (p = 1.74E-04) ** | rs3779505 | ITGB8 | Â | Â |
Regulation of actin cytoskeleton (p = 1.56E-03) | rs2301727 | ITGB8 | Â | Â |
Hypertrophic cardiomyopathy (HCM) (p = 1.22E-03) | rs3807936 | ITGB8 | Â | Â |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) (p = 9.12E-04) ** | Â | Â | Â | Â |
Dilated cardiomyopathy (p = 1.04E-03) | rs2158250 | ITGB8 | rs3779505 | ITGB8 |