Figure 3

Gene expression microarray analysis for finding miR-34a-regulated genes and biological modules. (A) A Venn diagram shows that 136 miR-34a-affected genes are decreased in 9d precursors [27]. These genes all contain putative miR-34a binding sites revealed by the miRTar webtool http://mirtar.mbc.nctu.edu.tw/human/. (B) The above 136 genes were subjected to the GO database search via the DAVID Bioinformatics Resources 6.7 database http://david.abcc.ncifcrf.gov/. These categories were selected from the Biological Process organizing principle in the GO project http://www.geneontology.org/. The number of genes and P values for each category are also listed. Underlined: discussed in the text. (C) Motility and oxidative phosphorylation genes (mapped by the WebGestalt http://bioinfo.vanderbilt.edu/webgestalt/ interface) which are targeted by miR-34a. Numbers of targets sites within the 3' UTR of each gene are shown.