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Table 1 Clinicopathological details

From: mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts

Category

Patient characteristics

Biopsies (%)

Cell lines (%)

Xenografts (%)

Total nr of samples

 

76 (100)

13 (100)

18 (100)

Institution

LUMC, Netherlands

29 (38.2)

0 (0)

0 (0)

 

IOR, Italy

11 (14.5)

7 (53.8)

0 (0)

 

LOH, Sweden

3 (3.9)

0 (0)

0 (0)

 

Radiumhospitalet, Norway

1 (1.3)

3 (23.1)

12 (66.7)

 

UV, Spain

0 (0)

0 (0)

6 (33.3)

 

WWUM, Germany

32 (42.1)

0 (0)

0 (0)

 

Other

0 (0)

3 (23.1)

0 (0)

Origin

Biopsy

76 (100)

0 (0)

0 (0)

 

Resection

0 (0)

7 (53.8)

11 (61.1)

 

Metastasis

0 (0)

3 (23.1)

1 (5.6)

 

Unknown

0 (0)

3 (23.1)

6 (33.3)

Location of primary tumor

Femur

36 (47.4)

0 (0)

10 (55.6)

 

Tibia/fibula

26 (34.2)

0 (0)

2 (11.1)

 

Humerus

10 (13.2)

0 (0)

2 (11.1)

 

Axial skeleton

1 (1.3)

0 (0)

1 (5.6)

 

Unknown/other

3 (3.9)

13 (100)

3 (16.7)

Histological subtype

Osteoblastic

50 (65.8)

9 (69.2)

15 (83.3)

 

Chondroblastic

9 (11.8)

0 (0)

3 (16.7)

 

Fibroblastic

7 (9.2)

4 (30.8)

0 (0)

 

Minor

10 (13.2)

0 (0)

0 (0)

Histological response to pre-operative chemotherapy in the primary tumor

Good response

33 (43.4)

0 (0)

0 (0)

 

Poor response

36 (47.4)

0 (0)

0 (0)

 

Unknown/NA

7 (9.2)

13 (100)

18 (100)

Sex

Male

52 (68.4)

9 (69.2)

9 (50)

 

Female

24 (31.6)

4 (30.8)

3 (16.7)

 

Unknown

0 (0)

0 (0)

6 (33.3)

  1. Clinicopathological details of patients with conventional high-grade osteosarcoma, including all patients from the biopsy, cell line, and xenograft datasets.