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Table 1 Clinicopathological details

From: mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts

Category Patient characteristics Biopsies (%) Cell lines (%) Xenografts (%)
Total nr of samples   76 (100) 13 (100) 18 (100)
Institution LUMC, Netherlands 29 (38.2) 0 (0) 0 (0)
  IOR, Italy 11 (14.5) 7 (53.8) 0 (0)
  LOH, Sweden 3 (3.9) 0 (0) 0 (0)
  Radiumhospitalet, Norway 1 (1.3) 3 (23.1) 12 (66.7)
  UV, Spain 0 (0) 0 (0) 6 (33.3)
  WWUM, Germany 32 (42.1) 0 (0) 0 (0)
  Other 0 (0) 3 (23.1) 0 (0)
Origin Biopsy 76 (100) 0 (0) 0 (0)
  Resection 0 (0) 7 (53.8) 11 (61.1)
  Metastasis 0 (0) 3 (23.1) 1 (5.6)
  Unknown 0 (0) 3 (23.1) 6 (33.3)
Location of primary tumor Femur 36 (47.4) 0 (0) 10 (55.6)
  Tibia/fibula 26 (34.2) 0 (0) 2 (11.1)
  Humerus 10 (13.2) 0 (0) 2 (11.1)
  Axial skeleton 1 (1.3) 0 (0) 1 (5.6)
  Unknown/other 3 (3.9) 13 (100) 3 (16.7)
Histological subtype Osteoblastic 50 (65.8) 9 (69.2) 15 (83.3)
  Chondroblastic 9 (11.8) 0 (0) 3 (16.7)
  Fibroblastic 7 (9.2) 4 (30.8) 0 (0)
  Minor 10 (13.2) 0 (0) 0 (0)
Histological response to pre-operative chemotherapy in the primary tumor Good response 33 (43.4) 0 (0) 0 (0)
  Poor response 36 (47.4) 0 (0) 0 (0)
  Unknown/NA 7 (9.2) 13 (100) 18 (100)
Sex Male 52 (68.4) 9 (69.2) 9 (50)
  Female 24 (31.6) 4 (30.8) 3 (16.7)
  Unknown 0 (0) 0 (0) 6 (33.3)
  1. Clinicopathological details of patients with conventional high-grade osteosarcoma, including all patients from the biopsy, cell line, and xenograft datasets.