| No. of genes with the motif from 826 promoter regionsa | p-value: skewing of up- or dnreg. | Prominent functional annotationb | |||
---|---|---|---|---|---|---|
TFBS motif | FSH upreg. | FSH dnreg. | Upreg./dnreg. | Â | FSH upreg. | FSH dnreg. |
MEF2A | 39 | 101 | 0.4 | < 0.0001 | PI3K signaling, 8 genes | muscle phenotype, 16 genes |
E4BP4 | 16 | 42 | 0.4 | 0.008 | cell adhesion, 5 genes, GO:0007155 | none |
PPARG | 100 | 43 | 2.3 | 0.0001 | extracellular matrix, 13 genes, GO:0031012; arachidonic acid, 15 genes | cardiac hypertrophy, 7 genes |
p53 | 84 | 37 | 2.3 | 0.0009 | inflammation, 29 genes; superoxide, 29 genes | Activation of cAMP-dependent PKA, 5 genes |