Skip to main content

Table 3 Some pathways and functional terms overrepresented among FSHD-dysregulated genes.

From: Gene expression during normal and FSHD myogenesis

Functional termsa Mb
or Mt
No. of up- or
dnreg. genes
Ratiob
RNA-induced silencing complex Mt 4 dn 0.80
  Mb 1 dn 0.20
Fatty acid elongation in mitochondria Mb 7 up 0.44
  Mt 2 up 0.13
Extracellular matrix Mt 35 up, 1 dn 0.30
  Mb 4 up, 2 dn 0.05
NRF2-mediated oxidative stress response Mt 15 up, 7 dn 0.13
  Mb 7 up 0.04
HIF1α Signaling Mt 6 up, 7 dn 0.12
  Mb 5 up 0.05
Regulation of actin-based motility by Rho Mt 9 up, 3 dn 0.10
  Mb 6 up 0.07
Mitochondrial matrix Mt 18 up, 5 dn 0.11
  Mb 22 up, 1 dn 0.11
Oxidative phosphorylation Mt 18 up 0.16
  Mb 11 up 0.09
Induction of apoptosis Mt 13 up, 5 dn 0.09
  Mb 8 up, 2 dn 0.05
Anti-apoptosis Mt 16 up, 3 dn 0.10
  Mb 4 up 0.02
  1. aOverrepresented functional terms for genes up- or downregulated (p < 0.01) in FSHD vs. control myoblasts (Mb) or myotubes (Mt) were identified by bioinformatics programs. Details and the names of the dysregulated genes are given in Additional File 8 Table S5.
  2. bThe number of genes for a given pathway or GO-term that were up- or downregulated in FSHD vs. control myogenic cells/the total number of genes for that pathway or GO-term that were included in the microarray.