Comparison of copy number profiles of different tumor biopsies. DNA read frequencies and subsequent normalized log ratios for tumor versus normal were determined for chromosomal intervals (bins) of 55-190 Kb. Copy number changes were calculated as running median of the log ratios of 20 bins. Differences in copy number between the two foci of one tumor are depicted as the difference of the two running median vectors. Differences greater or equal 0.2 were highlighted in magenta.