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Table 2 Significantly changed secreted proteins in adipose tissue culture media and the corresponding identified genes in adipose tissue and liver tissue upon LPS-treatment

From: Comparative analysis of the human hepatic and adipose tissue transcriptomes during LPS-induced inflammation leads to the identification of differential biological pathways and candidate biomarkers

NAME SYMBOL AT FC-protein avg AT LPS+ protein avg AT LPS- protein std AT LPS+ protein std AT LPS- protein AT (p val.) FC- transcriptome LT (p val.) FC- transcriptome
Leukemia inhibitory factor LIF 2.3 6, 6 2, 9 0, 22 0, 41 (0, 000) 7, 2 (ns) 2.9
Fractalkine CX3CL1 4.3 4, 3 1, 0 0, 24 0, 10 (0, 000) 6.4 (ns) 9, 9
Tumor necrosis factor TNF 3.8 4, 8 1, 3 0, 95 0, 15 (0, 000) 6 (ns) 1.7
Plasminogen activator inhibitor 2 SERPINB2 3.1 2, 6 0, 8 0, 41 0, 05 (0, 000) 6 (0, 002) 8
Interleukin-6 IL6 1.6 6, 9 4, 7 0, 31 0, 07 (0, 000) 4.5 (0, 01) 17.8
Pentraxin-related protein PTX3 1.9 3, 5 1, 8 0, 70 0, 14 (0, 000) 4 (ns)2.1
Interstitial collagenase MMP1 1.7 4, 7 2, 7 0, 16 0, 17 (0, 000) 3.4 (ns)-1.1
Tumor necrosis factor-inducible gene 6 protein TNFAIP6 5.4 4, 8 0, 9 0, 95 0, 20 (0, 000) 3.1 (0, 000)17.9
Plasminogen activator inhibitor 1 SERPINE1 1.7 4, 0 2, 5 0, 19 0, 12 (0, 000) 3 (ns)1.7
C-C motif chemokine 2 CCL2 6.9 6, 9 1, 0 0, 11 0, 10 (0, 000) 2.3 (0, 004) 3.7
CD44 antigen CD44 2.4 0, 3 0, 1 0, 01 0, 02 (ns) 1.7 (0, 000) 5.8
Insulin-like growth factor-binding protein 4 IGFBP4 -2.5 1, 4 3, 6 0, 10 0, 26 (ns)-1.1 (ns)1.2
Adipocyte enhancer-binding protein 1 AEBP1 -1.4 0, 2 0, 2 0, 00 0, 01 (ns)-1.2 (ns)1.2
Cystatin-C CST3 -3.1 0, 8 2, 6 0, 06 0, 17 (ns)-1.2 (ns) -1.1
Versican core protein VCAN -2 0, 1 0, 2 0, 01 0, 01 (ns)-1.6 (ns) -1.4
Collagen alpha-1(VI) chain COL6A1 -3.3 0, 4 1, 3 0, 27 0, 18 (ns)-1.6 (ns) -1.4
Transforming growth factor-beta-induced protein ig-h3 TGFBI -2.5 0, 1 0, 1 0, 00 0, 01 (ns)-1.6 (ns) 1
Legumain LGMN -3.1 0, 9 2, 7 0, 06 0, 17 (0, 002)-2 (ns) 1.2
Gelsolin GSN -2.5 0, 1 0, 4 0, 03 0, 02 (0.002)-2 (ns) 1.1
Cathepsin B CTSB -1.2 2, 2 2, 7 0, 04 0, 04 (ns) -2 (ns) -1.2
Lysozyme C LYZ -3.3 0, 1 0, 3 0, 01 0, 04 (0, 001) -2.5 (ns) -3.3
Alpha-2-macroglobulin A2M -3.3 0, 3 1, 1 0, 04 0, 06 (0, 000) -3.3 (ns) -1.6
  1. Fold change (FC) for the significantly changed proteins (p ≤ 0.05, FC > 1.2) in adipose tissue (AT) n = 1 and the significantly changed genes (p ≤ 0.05, FC > 2, n = 7 for adipose tissue and n = 5 for liver tissue (LT)) is represented in bold, p value is given in brackets (...). The insignificantly affected genes (ns) are depicted in italics. FC was calculated in LPS treated samples (LPS+) compared to control samples (LPS-). Additionally, information about average (avg) value in proteomics experiment representative for protein expression and its standard deviation (std) are depicted in the table. The top candidate biomarkers related to inflamed adipose tissue are depicted in bold and underlined.