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Table 2 Differentially expressed genes in peripheral blood lymphocytes from ALS patients by SAM (q = 0) ranked by independent LIMMA (p < 0.0005)

From: Microarray analysis of peripheral blood lymphocytes from ALS patients and the SAFE detection of the KEGG ALS pathway

αProbe

βSymbol

γGene Description

δp value

εq value

χFC

A23P8185

DYNLT1

dynein, light chain, Tctex-type 1

0.000004

0.028

1.5

A24P154037

IRS2

insulin receptor substrate 2

0.000015

0.048

0.5

A32P234935

TARDBP

TAR DNA binding protein

0.000024

0.048

1.6

A23P98930

C12orf35

chromosome 12 open reading frame 35

0.000031

0.048

1.6

A23P110661

SKIV2L2

superkiller viralicidic activity 2-like 2

0.000033

0.048

1.8

A23P104624

ENDOD1

endonuclease domain containing 1

0.000069

0.083

1.5

A23P317800

ANAPC4

anaphase promoting complex subunit 4

0.000106

0.100

1.4

A23P21673

KIAA1797

KIAA1797

0.000150

0.100

1.5

A23P145437

PHIP

pleckstrin homology domain interacting protein

0.000185

0.100

1.4

A23P15714

NSF

N-ethylmaleimide-sensitive factor

0.000210

0.100

1.6

A23P82588

C7orf55

chromosome 7 open reading frame 55

0.000234

0.100

1.6

A23P120153

RNF149

ring finger protein 149

0.000290

0.100

1.7

A23P70998

tcag7.903

full-length cDNA clone CS0DF028YG12

0.000308

0.100

1.5

A23P145874

SAMD9L

sterile alpha motif domain containing 9-like

0.000310

0.100

2.1

A24P172481

TRIM22

tripartite motif-containing 22

0.000319

0.100

1.5

A23P42664

SHFM1

split hand/foot malformation (ectrodactyly) type 1

0.000328

0.100

1.6

A23P156355

TMEM161B

transmembrane protein 161B

0.000340

0.100

1.5

A23P129925

SLFN11

schlafen family member 11

0.000364

0.100

1.5

A24P209455

GIMAP4

GTPase, IMAP family member 4

0.000383

0.100

1.8

A23P84775

PLRG1

pleiotropic regulator 1

0.000386

0.100

1.5

A23P213255

SMARCAD1

SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing 1 DEAD/H box 1

0.000445

0.100

1.6

A23P19565

ASCC3

activating signal cointegrator 1 complex subunit 3

0.000457

0.100

1.4

A23P61854

KIAA0372

tetratricopeptide repeat protein 37

0.000461

0.100

1.4

A23P91891

COPB2

coatomer protein complex, subunit beta 2

0.000471

0.100

1.9

  1. The list presents the 24 most discriminatory genes distinguishing the definite sALS patients (n = 11) from the healthy control subjects (n = 11). αAgilent Array 4 × 44K probe ID, βgene symbol, γdescription, δLIMMA significance p value, εLIMMA FDR (q value), and χfold change (FC) in expression are indicated. Using the TM4-MIDAS/TMeV pipeline, all genes had a local FDR of q = 0 according to SAM performed on DS7000 [7199 probes, 5540 unique genes]. Five genes had a LIMMA q value ≤0.05: DYNLT1, IRS2, TARDBP, C12orf35, and SKIV2L2.
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BMC Medical Genomics

ISSN: 1755-8794

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