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Table 2 Differentially expressed genes in peripheral blood lymphocytes from ALS patients by SAM (q = 0) ranked by independent LIMMA (p < 0.0005)

From: Microarray analysis of peripheral blood lymphocytes from ALS patients and the SAFE detection of the KEGG ALS pathway

αProbe βSymbol γGene Description δp value εq value χFC
A23P8185 DYNLT1 dynein, light chain, Tctex-type 1 0.000004 0.028 1.5
A24P154037 IRS2 insulin receptor substrate 2 0.000015 0.048 0.5
A32P234935 TARDBP TAR DNA binding protein 0.000024 0.048 1.6
A23P98930 C12orf35 chromosome 12 open reading frame 35 0.000031 0.048 1.6
A23P110661 SKIV2L2 superkiller viralicidic activity 2-like 2 0.000033 0.048 1.8
A23P104624 ENDOD1 endonuclease domain containing 1 0.000069 0.083 1.5
A23P317800 ANAPC4 anaphase promoting complex subunit 4 0.000106 0.100 1.4
A23P21673 KIAA1797 KIAA1797 0.000150 0.100 1.5
A23P145437 PHIP pleckstrin homology domain interacting protein 0.000185 0.100 1.4
A23P15714 NSF N-ethylmaleimide-sensitive factor 0.000210 0.100 1.6
A23P82588 C7orf55 chromosome 7 open reading frame 55 0.000234 0.100 1.6
A23P120153 RNF149 ring finger protein 149 0.000290 0.100 1.7
A23P70998 tcag7.903 full-length cDNA clone CS0DF028YG12 0.000308 0.100 1.5
A23P145874 SAMD9L sterile alpha motif domain containing 9-like 0.000310 0.100 2.1
A24P172481 TRIM22 tripartite motif-containing 22 0.000319 0.100 1.5
A23P42664 SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.000328 0.100 1.6
A23P156355 TMEM161B transmembrane protein 161B 0.000340 0.100 1.5
A23P129925 SLFN11 schlafen family member 11 0.000364 0.100 1.5
A24P209455 GIMAP4 GTPase, IMAP family member 4 0.000383 0.100 1.8
A23P84775 PLRG1 pleiotropic regulator 1 0.000386 0.100 1.5
A23P213255 SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing 1 DEAD/H box 1 0.000445 0.100 1.6
A23P19565 ASCC3 activating signal cointegrator 1 complex subunit 3 0.000457 0.100 1.4
A23P61854 KIAA0372 tetratricopeptide repeat protein 37 0.000461 0.100 1.4
A23P91891 COPB2 coatomer protein complex, subunit beta 2 0.000471 0.100 1.9
  1. The list presents the 24 most discriminatory genes distinguishing the definite sALS patients (n = 11) from the healthy control subjects (n = 11). αAgilent Array 4 × 44K probe ID, βgene symbol, γdescription, δLIMMA significance p value, εLIMMA FDR (q value), and χfold change (FC) in expression are indicated. Using the TM4-MIDAS/TMeV pipeline, all genes had a local FDR of q = 0 according to SAM performed on DS7000 [7199 probes, 5540 unique genes]. Five genes had a LIMMA q value ≤0.05: DYNLT1, IRS2, TARDBP, C12orf35, and SKIV2L2.