αProbe | βSymbol | γAccession | δFC | εFunctional Description |
---|---|---|---|---|
A_23_P317800 | ANAPC4 | NM_013367 | 1.40 | anaphase promoting complex subunit 4: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains |
A_23_P106741 | PSMD7 | NM_002811 | 1.41 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins |
A_23_P120153 | RNF149 | NM_173647 | 1.67 | E3 ubiquitin-protein ligase RNF149: Unknown |
A_23_P42664 | SHFM1 | NM_006304 | 1.63 | split hand/foot malformation (ectrodactyly) type 1: Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis |
A_24_P172481 | TRIM22 | NM_006074 | 1.55 | E3 ubiquitin-protein ligase TRIM22: Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV corepromoter. May have E3 ubiquitin-protein ligase activity. |
A_23_P203137 | UBE4A | NM_004788 | 1.34 | ubiquitin conjugation factor E4 A: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3. |
A_23_P152066 | UBR1 | NM_174916 | 1.33 | ubiquitin protein ligase E3 component n-recognin 1: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. |
A_23_P362637 | UBR2 | NM_015255 | 1.25 | ubiquitin protein ligase E3 component n-recognin 2: Same as for UBR1 |
A_32_P178945 | YOD1 | NM_018566 | 1.52 | YOD1 OTU deubiquinating enzyme 1 homolog alias HIV-1-induced protease: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di-ubiquitin. |