Table 1 The most altered modules based on all comparisons.
From: Gene network analyses point to the importance of human tissue kallikreins in melanoma progression
MODULES | TUMOR SUBTYPE | MELANOMA PROGRESSION | CANCER STAGEb | METASTASIS SITE | CLINICAL OUTCOMEc | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PCM | MM | T1+T2a | T3a | T4a | MM | I | II | III | IV | LN | CUT | VISC | S | D | |
Cell communication (GD) | 0.5 | -0.4 | 0.0 | 0.0 | 0.0 | -0.4 | 0.0 | 0.0 | 0.0 | -0.4 | 0.0 | -0.4 | 0.0 | --- | --- |
Functionally hKLK-related genes | 0.5 | -0.2 | 0.0 | 0.7 | 0.0 | -0.2 | 0.0 | 0.6 | 0.0 | 0.0 | --- | --- | --- | --- | --- |
Epidermal development (GO8544) | 0.5 | -0.2 | 0.0 | 0.0 | 0.0 | -0.2 | 0.0 | 0.5 | 0.0 | -0.3 | --- | --- | --- | --- | --- |
Peptidase activity (GO8233) | 0.3 | 0.0 | 0.7 | 0.0 | 0.0 | 0.0 | --- | --- | --- | --- | --- | --- | --- | --- | --- |
Neuroactive ligand receptor (GD) | 0.2 | 0.0 | 0.0 | 0.5 | 0.0 | 0.0 | --- | --- | --- | --- | --- | --- | --- | --- | --- |
Metastasis signature | 0.0 | -0.4 | 0.0 | 0.0 | 0.0 | -0.4 | 0.0 | 0.0 | 0.0 | -0.5 | --- | --- | --- | --- | --- |
Cell adhesion (GO7155) | 0.0 | -0.3 | 0.0 | 0.0 | 0.0 | -0.3 | --- | --- | --- | --- | --- | --- | --- | --- | --- |
Prostaglandin and leukotriene metabolism (GD) | --- | --- | 0.0 | -0.3 | 0.0 | 0.0 | --- | --- | --- | --- | --- | --- | --- | --- | --- |
Intercellular junction (GO5911) | --- | --- | 0.7 | 0.0 | 0.0 | 0.0 | --- | --- | --- | --- | --- | --- | --- | --- | --- |
Nervous system development (GO7399) | --- | --- | 0.7 | 0.0 | 0.0 | 0.0 | --- | --- | --- | --- | --- | --- | --- | --- | --- |
Negative regulation of progression through cell cycle (GO45786) | --- | --- | --- | --- | --- | --- | 0.0 | 0.0 | 0.0 | -0.2 | --- | --- | --- | --- | --- |
Inflammatory response (GO6954) | --- | --- | --- | --- | --- | --- | 0.0 | 0.0 | 0.2 | 0.0 | --- | --- | --- | --- | --- |
Hydrolase activity (GO16787) | --- | --- | --- | --- | --- | --- | 0.0 | 0.3 | 0.0 | 0.0 | --- | --- | --- | --- | --- |
Extracellular region (GO5576) | --- | --- | --- | --- | --- | --- | 0.0 | 0.0 | 0.0 | -0.5 | --- | --- | --- | --- | --- |
Extracellular matrix sensu Metazoa (GO5578) | --- | --- | --- | --- | --- | --- | 0.0 | 0.0 | 0.0 | -0.4 | --- | --- | --- | --- | --- |
Cell motility (GO6928) | --- | --- | --- | --- | --- | --- | 0.0 | 0.0 | 0.0 | -0.2 | --- | --- | --- | --- | --- |
Alzheimers disease (GD) | --- | --- | --- | --- | --- | --- | 0.0 | 0.0 | 0.0 | 0.2 | --- | --- | --- | --- | --- |
G Protein signaling (GO7187) | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | -0.2 | 0.0 | 0.0 | --- | --- |
Leukocyte transendothelial migration | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | 0.2 | 0.0 | 0.0 | --- | --- |
Integral to plasma membrane (GO5887) | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | 0.3 | 0.0 | 0.0 | --- | --- |
Antigen processing and presentation (GD) | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | 0.3 | 0.0 | 0.0 | --- | --- |
Response to stress (GO6950) | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | 0.0 | 0.0 | -0.7 | -0.4 | 0.0 |