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Table 1 The most altered modules based on all comparisons.

From: Gene network analyses point to the importance of human tissue kallikreins in melanoma progression

MODULES TUMOR SUBTYPE MELANOMA PROGRESSION CANCER STAGEb METASTASIS SITE CLINICAL OUTCOMEc
  PCM MM T1+T2a T3a T4a MM I II III IV LN CUT VISC S D
Cell communication (GD) 0.5 -0.4 0.0 0.0 0.0 -0.4 0.0 0.0 0.0 -0.4 0.0 -0.4 0.0 --- ---
Functionally hKLK-related genes 0.5 -0.2 0.0 0.7 0.0 -0.2 0.0 0.6 0.0 0.0 --- --- --- --- ---
Epidermal development (GO8544) 0.5 -0.2 0.0 0.0 0.0 -0.2 0.0 0.5 0.0 -0.3 --- --- --- --- ---
Peptidase activity (GO8233) 0.3 0.0 0.7 0.0 0.0 0.0 --- --- --- --- --- --- --- --- ---
Neuroactive ligand receptor (GD) 0.2 0.0 0.0 0.5 0.0 0.0 --- --- --- --- --- --- --- --- ---
Metastasis signature 0.0 -0.4 0.0 0.0 0.0 -0.4 0.0 0.0 0.0 -0.5 --- --- --- --- ---
Cell adhesion (GO7155) 0.0 -0.3 0.0 0.0 0.0 -0.3 --- --- --- --- --- --- --- --- ---
Prostaglandin and leukotriene metabolism (GD) --- --- 0.0 -0.3 0.0 0.0 --- --- --- --- --- --- --- --- ---
Intercellular junction (GO5911) --- --- 0.7 0.0 0.0 0.0 --- --- --- --- --- --- --- --- ---
Nervous system development (GO7399) --- --- 0.7 0.0 0.0 0.0 --- --- --- --- --- --- --- --- ---
Negative regulation of progression through cell cycle (GO45786) --- --- --- --- --- --- 0.0 0.0 0.0 -0.2 --- --- --- --- ---
Inflammatory response (GO6954) --- --- --- --- --- --- 0.0 0.0 0.2 0.0 --- --- --- --- ---
Hydrolase activity (GO16787) --- --- --- --- --- --- 0.0 0.3 0.0 0.0 --- --- --- --- ---
Extracellular region (GO5576) --- --- --- --- --- --- 0.0 0.0 0.0 -0.5 --- --- --- --- ---
Extracellular matrix sensu Metazoa (GO5578) --- --- --- --- --- --- 0.0 0.0 0.0 -0.4 --- --- --- --- ---
Cell motility (GO6928) --- --- --- --- --- --- 0.0 0.0 0.0 -0.2 --- --- --- --- ---
Alzheimers disease (GD) --- --- --- --- --- --- 0.0 0.0 0.0 0.2 --- --- --- --- ---
G Protein signaling (GO7187) --- --- --- --- --- --- --- --- --- --- -0.2 0.0 0.0 --- ---
Leukocyte transendothelial migration --- --- --- --- --- --- --- --- --- --- 0.2 0.0 0.0 --- ---
Integral to plasma membrane (GO5887) --- --- --- --- --- --- --- --- --- --- 0.3 0.0 0.0 --- ---
Antigen processing and presentation (GD) --- --- --- --- --- --- --- --- --- --- 0.3 0.0 0.0 --- ---
Response to stress (GO6950) --- --- --- --- --- --- --- --- --- --- 0.0 0.0 -0.7 -0.4 0.0
  1. The modules are listed by values representing their status (induced or repressed). Induced modules are depicted by positive values and repressed modules by negative values.
  2. The modules in italic were selected for showing changes in at least four different groups in distinct category types.
  3. aBreslow's thickness index according to AJCC staging system. bCancer stage according to the AJCC staging system. c Follow up set as more than 4 years: S = surviving, D = death.