Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features

BMC Medical Genomics

Table 2 Comparison of cluster 1 and cell types/subtypes from published gene lists

Comparison	Reference	Cluster 1 resembles	P-value
Epithelial vs stem-like cell	Shipitsin, 2007	Stem-like cell	2.20E-16
Stroma vs epithelium	Finak, 2006	Stroma	2.20E-16
Mesenchymal vs epithelial	Jechlinger, 2003	Mesenchymal	6.90E-14
Revised subtypes	Herschkowitz, 2007	Claudin-low	1.52E-12
Fibroblasts vs epithelial cells	Casey, 2008	Fibroblasts	1.9E-12
Risk predictor	Chen, 2009	Low risk	1.30E-09
Stem-like cell vs epithelial	Liu, 2007	Stem-like	1.30E-05
Myoepithelial vs progenitor	Raouf, 2008	Progenitor	2.40E-05
Luminal vs progenitor	Raouf, 2008	Progenitor	0.001
Stem-like vs progenitor cells	Villadsen, 2007	Lineage restricted progenitor	0.008
Myoepithelial vs luminal	Jones, 2004	(Myepithelial)	0.06
Classical subtypes	Sorlie, 2001	-	0.76

*) Chi squared test for significance
Chi-squared test is used to illustrate the extent to which genes describing different cell types are equally regulated in the two clusters. Significant p-values are in bold type. For more information on the publications and comparisons, see Supplemental file 3, Table S3.

ISSN: 1755-8794