Table 2 KEGG pathways enriched by DEGs, all DEmiRNA target genes and all DEmiRNA target DEGs.
From: Systems biology of interstitial lung diseases: integration of mRNA and microRNA expression changes
| Â | Â | All DEGs | All DEmiRNA predicted targets | DEGs that are DEmiRNA predicted targets | |||
|---|---|---|---|---|---|---|---|
KEGG pathway | Up-regulated DEGs | Down-regulated DEGs | All targets of down-regulated DEmiRNAs | All targets of up-regulated DEmiRNAs | DEG targets of down-regulated DEmiRNAs | DEG targets of up-regulated DEmiRNAs | |
Signal Transduction | Calcium signaling pathway | 4.0E-01 | 1.0E + 00 | 4.6E-04 | 2.7E-03 | 4.1E-02 | 9.5E-01 |
| Â | ErbB signaling pathway | 3.4E-01 | 3.5E-01 | 9.3E-05 | 6.4E-08 | 1.3E-01 | 4.2E-01 |
| Â | Hedgehog signaling pathway | 4.2E-02 | 4.7E-01 | 2.8E-02 | 6.2E-04 | 8.1E-03 | 6.1E-01 |
| Â | Jak-STAT signaling pathway | 6.0E-01 | 3.9E-01 | 7.6E-02 | 7.6E-02 | 1.0E-01 | 2.5E-01 |
| Â | MAPK signaling pathway | 2.0E-01 | 9.5E-02 | 1.7E-08 | 1.3E-16 | 1.3E-01 | 1.6E-01 |
| Â | mTOR signaling pathway | 5.3E-01 | 2.0E-01 | 1.1E-02 | 2.6E-07 | 1.0E + 00 | 5.3E-02 |
| Â | Notch signaling pathway | 7.2E-02 | 1.6E-01 | 1.4E-01 | 5.4E-03 | 2.9E-01 | 5.4E-01 |
| Â | Phosphatidylinositol signaling system | 2.5E-01 | 8.6E-01 | 8.2E-05 | 3.9E-06 | 1.1E-01 | 3.6E-01 |
| Â | TGF-beta signaling pathway | 3.4E-01 | 5.5E-01 | 4.3E-08 | 1.9E-06 | 4.8E-01 | 1.0E + 00 |
| Â | VEGF signaling pathway | 2.5E-01 | 1.2E-01 | 7.4E-02 | 2.2E-03 | 4.3E-01 | 3.6E-02 |
| Â | Wnt signaling pathway | 4.9E-03 | 7.4E-03 | 1.4E-05 | 1.3E-14 | 7.2E-04 | 3.3E-03 |
Signaling Molecules and interactions | Cell adhesion molecules (CAMs) | 8.1E-02 | 9.4E-01 | 8.4E-01 | 2.9E-01 | 7.4E-02 | 6.5E-01 |
| Â | ECM-receptor interaction | 5.7E-07 | 9.0E-01 | 2.7E-04 | 9.3E-06 | 3.1E-03 | 1.0E + 00 |
Behavior | Circadian rhythm - mammal | 1.0E + 00 | 1.1E-01 | 3.1E-02 | 1.6E-02 | 1.0E + 00 | 1.9E-01 |
Cell Communication | Adherens junction | 1.2E-01 | 9.7E-01 | 1.1E-04 | 1.1E-09 | 4.3E-01 | 1.0E + 00 |
| Â | Focal adhesion | 9.6E-09 | 5.5E-01 | 1.4E-07 | 8.8E-17 | 3.1E-03 | 8.5E-01 |
| Â | Gap junction | 3.7E-01 | 1.0E + 00 | 1.1E-02 | 4.7E-06 | 2.8E-02 | 1.0E + 00 |
| Â | Tight junction | 4.7E-01 | 3.9E-01 | 8.3E-03 | 3.9E-06 | 6.3E-01 | 1.8E-01 |
Cell Growth and Death | Apoptosis | 8.1E-01 | 4.4E-02 | 2.7E-02 | 6.5E-03 | 1.0E + 00 | 4.3E-01 |
| Â | Cell cycle | 9.4E-01 | 3.5E-01 | 7.3E-03 | 1.4E-01 | 6.2E-01 | 8.9E-01 |
| Â | p53 signaling pathway | 6.8E-01 | 8.6E-02 | 1.5E-02 | 4.4E-03 | 4.0E-01 | 3.1E-01 |
Cell Motility | Regulation of actin cytoskeleton | 1.9E-01 | 5.0E-01 | 2.2E-05 | 1.4E-12 | 4.7E-01 | 4.8E-01 |
Circulatory System | Vascular smooth muscle contraction | 5.6E-06 | 1.0E + 00 | 3.0E-03 | 1.0E-03 | 1.6E-04 | 1.0E + 00 |
Development | Axon guidance | 6.8E-02 | 6.9E-01 | 1.2E-08 | 3.9E-15 | 6.7E-02 | 3.6E-01 |
| Â | Dorso-ventral axis formation | 5.8E-01 | 1.0E + 00 | 4.0E-04 | 1.3E-02 | 1.0E + 00 | 1.0E + 00 |
Endocrine System | Adipocytokine signaling pathway | 3.9E-01 | 1.5E-04 | 2.0E-02 | 2.3E-05 | 3.9E-01 | 7.4E-04 |
| Â | GnRH signaling pathway | 2.6E-01 | 4.8E-01 | 4.8E-03 | 1.6E-04 | 3.8E-02 | 2.4E-01 |
| Â | Insulin signaling pathway | 2.2E-03 | 1.9E-02 | 2.6E-03 | 7.0E-11 | 7.9E-02 | 2.5E-02 |
| Â | Melanogenesis | 6.8E-01 | 9.9E-01 | 2.9E-03 | 1.2E-06 | 1.7E-01 | 8.2E-01 |
| Â | PPAR signaling pathway | 1.0E + 00 | 1.9E-01 | 6.6E-01 | 8.1E-01 | 1.0E + 00 | 2.6E-02 |