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Table 5 Top most regulated genes after BMP4 signaling.

From: Analysis of BMP4 and BMP7 signaling in breast cancer cells unveils time-dependent transcription patterns and highlights a common synexpression group of genes

    # regulated events
Gene Id Gene name Gene description Up Down Total
ENSG00000144724 PTPRG protein tyrosine phosphatase, receptor type, G 23 0 23
ENSG00000125968 ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 19 0 19
ENSG00000179088 C12orf42 uncharacterized protein C12orf42 19 0 19
ENSG00000158050 DUSP2 dual specificity phosphatase 2 18 0 18
ENSG00000109163 GNRHR gonadotropin-releasing hormone receptor 18 0 18
ENSG00000234906 APOC2 apolipoprotein C-II 18 0 18
ENSG00000117318 ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 17 0 17
ENSG00000115738 ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 16 0 16
ENSG00000172201 ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 16 0 16
ENSG00000197442 MAP3K5 mitogen-activated protein kinase kinase kinase 5 15 0 15
ENSG00000127129 EDN2 endothelin 2 15 0 15
ENSG00000164850 GPER G protein-coupled estrogen receptor 1 15 0 15
ENSG00000181638 ZFP41 zinc finger protein 41 homolog (mouse) 15 0 15
ENSG00000181626 ANKRD62 ankyrin repeat domain 62 15 0 15
ENSG00000187957 DNER delta/notch-like EGF repeat containing 14 0 14
ENSG00000238243 OR2W3 olfactory receptor, family 2, subfamily W, member 3 14 0 14
ENSG00000164683 HEY1 hairy/enhancer-of-split related with YRPW motif 1 14 0 14
ENSG00000157322 CLEC18A C-type lectin domain family 18, member A 13 1 14
ENSG00000247097 C14orf184 Putative uncharacterized protein C14orf184 8 6 14
ENSG00000212124 TAS2R19 taste receptor, type 2, member 19 9 4 13
ENSG00000186115 CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 6 7 13
ENSG00000176472 ZNF575 zinc finger protein 575 7 6 13
ENSG00000181722 ZBTB20 zinc finger and BTB domain containing 20 7 6 13
ENSG00000163827 LRRC2 leucine rich repeat containing 2 12 0 12
ENSG00000214049 UCA1 urothelial cancer associated 1 12 0 12
ENSG00000132854 KANK4 KN motif and ankyrin repeat domains 4 12 0 12
ENSG00000163749 CCDC158 coiled-coil domain containing 158 12 0 12
ENSG00000100029 PES1 pescadillo homolog 1, containing BRCT domain (zebrafish) 0 12 12
ENSG00000120645 IQSEC3 IQ motif and Sec7 domain 3 0 12 12
ENSG00000122852 SFTPA1 surfactant protein A1 9 3 12
ENSG00000052802 SC4MOL sterol-C4-methyl oxidase-like 9 3 12
ENSG00000197532 OR6Y1 olfactory receptor, family 6, subfamily Y, member 1 8 4 12
ENSG00000078328 RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 8 4 12
ENSG00000185010 F8 coagulation factor VIII, procoagulant component 8 4 12
ENSG00000115756 HPCAL1 hippocalcin-like 1 8 4 12
ENSG00000122859 NEUROG3 neurogenin 3 5 7 12
ENSG00000186810 CXCR3 chemokine (C-X-C motif) receptor 3 6 6 12
ENSG00000168874 ATOH4 atonal homolog 8 (Drosophila) 11 0 11
ENSG00000040731 CDH10 cadherin 10, type 2 (T2-cadherin) 11 0 11
ENSG00000168930 TRIM49 tripartite motif-containing 49 11 0 11
ENSG00000104863 LIN7B lin-7 homolog B (C. elegans) 11 0 11
ENSG00000113391 FAM172A microRNA 2277 11 0 11
ENSG00000162614 NEXN nexilin (F actin binding protein) 11 0 11
ENSG00000120693 SMAD9 SMAD family member 9 11 0 11
ENSG00000176907 C8orf4 Uncharacterized protein C8orf4 (Thyroid cancer protein 1)(TC-1) 10 1 11
ENSG00000085224 ATRX alpha thalassemia/mental retardation syndrome X-linked 10 1 11
ENSG00000163743 RCHY1 ring finger and CHY zinc finger domain containing 1 9 2 11
ENSG00000006007 GDE1 glycerophosphodiester phosphodiesterase 1 9 2 11
ENSG00000114850 SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 9 2 11
ENSG00000109472 CPE carboxypeptidase E 9 2 11
ENSG00000106608 URGCP upregulator of cell proliferation 2 9 11
ENSG00000064201 TSPAN32 tetraspanin 32 8 3 11
ENSG00000212128 TAS2R13 taste receptor, type 2, member 13 8 3 11
ENSG00000092871 RFFL ring finger and FYVE-like domain containing 1 7 4 11
ENSG00000139880 CDH24 cadherin 24, type 2 4 7 11
ENSG00000039319 ZFYVE16 zinc finger, FYVE domain containing 16 4 7 11
ENSG00000206052 DOK6 docking protein 6 6 5 11
ENSG00000050165 DKK3 dickkopf homolog 3 (Xenopus laevis) 5 6 11
ENSG00000115844 DLX2 distal-less homeobox 2 10 0 10
ENSG00000178343 SHISA3 shisa homolog 3 (Xenopus laevis) 10 0 10
ENSG00000123329 ARHGAP9 Rho GTPase activating protein 9 10 0 10
ENSG00000145287 PLAC8 placenta-specific 8 10 0 10
ENSG00000187634 SAMD11 sterile alpha motif domain containing 11 10 0 10
ENSG00000167962 ZNF598 zinc finger protein 598 10 0 10
ENSG00000003509 C2orf56 Protein midA homolog, mitochondrial Precursor 8 2 10
ENSG00000143153 ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 8 2 10
ENSG00000189079 ARID2 AT rich interactive domain 2 (ARID, RFX-like) 2 8 10
ENSG00000162706 CADM3 cell adhesion molecule 3 7 3 10
ENSG00000147488 ST18 suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) 7 3 10
ENSG00000182175 RGMA RGM domain family, member A 7 3 10
ENSG00000163623 NKX6-1 NK6 homeobox 1 3 7 10
ENSG00000144559 C3orf31 MMP37-like protein, mitochondrial Precursor 6 4 10
ENSG00000153002 CPB1 carboxypeptidase B1 (tissue) 6 4 10
ENSG00000181965 NEUROG1 neurogenin 1 6 4 10
ENSG00000171564 FGB fibrinogen beta chain 6 4 10
ENSG00000132612 VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 6 4 10
ENSG00000183023 SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 4 6 10
ENSG00000166748 AGBL1 ATP/GTP binding protein-like 1 5 5 10
ENSG00000204882 GPR20 G protein-coupled receptor 20 5 5 10
ENSG00000159216 RUNX1 runt-related transcription factor 1 5 5 10
  1. Differentially expressed genes resulting from the general filtering of BMP4 data (1, 678) were ranked according to the number of times a gene was up- and downregulated throughout the series of cell lines and time points. Only those genes with total rank value of at least 10 are listed.