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Table 3 Functional annotation clustering of genes with hypermethylated 5'CGIs

From: Identification of DNA methylation changes associated with human gastric cancer

Annotation Cluster 1

Enrichment Score: 3.27

Count

P_Value

GOTERM_BP_FAT

nucleosome assembly

11

3.90E-04

GOTERM_BP_FAT

chromatin assembly

11

5.20E-04

GOTERM_BP_FAT

protein-DNA complex assembly

11

7.40E-04

Annotation Cluster 2

Enrichment Score: 2.92

Count

P_Value

INTERPRO

Histone core

8

6.80E-04

SP_PIR_KEYWORDS

nucleosome core

8

8.60E-04

GOTERM_CC_FAT

nucleosome

8

3.10E-03

Annotation Cluster 3

Enrichment Score: 2.16

Count

P_Value

INTERPRO

Homeobox, conserved site

17

5.10E-03

INTERPRO

Homeobox

17

5.70E-03

SP_PIR_KEYWORDS

Homeobox

17

5.80E-03

INTERPRO

Homeodomain-related

17

6.40E-03

SMART

HOX

17

1.40E-02

Annotation Cluster 4

Enrichment Score: 2.02

Count

P_Value

PIR_SUPERFAMILY

brain-expressed X-linked protein

3

9.10E-03

PIR_SUPERFAMILY

PIRSF008633:BEX

3

9.10E-03

INTERPRO

Brain expressed X-linked like protein

3

1.00E-02

Annotation Cluster 5

Enrichment Score: 1.97

Count

P_Value

PIR_SUPERFAMILY

PIRSF002051:histone H3

3

9.10E-03

INTERPRO

Histone H3

3

1.00E-02

SMART

H3

3

1.30E-02

Annotation Cluster 6

Enrichment Score: 1.78

Count

P_Value

UP_SEQ_FEATURE

domain:Helix-loop-helix motif

10

1.20E-02

INTERPRO

Basic helix-loop-helix dimerisation region bHLH

10

1.40E-02

SMART

HLH

10

2.60E-02

Annotation Cluster 7

Enrichment Score: 1.77

Count

P_Value

GOTERM_CC_FAT

focal adhesion

9

1.30E-02

GOTERM_CC_FAT

cell-substrate adherens junction

9

1.60E-02

GOTERM_CC_FAT

cell-substrate junction

9

2.20E-02

Annotation Cluster 8

Enrichment Score: 1.55

Count

P_Value

GOTERM_BP_FAT

regulation of B cell proliferation

5

1.20E-02

GOTERM_BP_FAT

positive regulation of B cell activation

5

2.20E-02

GOTERM_BP_FAT

regulation of B cell activation

5

8.40E-02

Annotation Cluster 9

Enrichment Score: 1.55

Count

P_Value

PIR_SUPERFAMILY

PIRSF500606:homeotic protein Hox D4

3

9.10E-03

SP_PIR_KEYWORDS

embryo

3

3.30E-02

PIR_SUPERFAMILY

PIRSF002612:homeotic protein Hox A5/D4

3

3.70E-02

INTERPRO

Homeobox protein, antennapedia type

3

5.90E-02

Annotation Cluster 10

Enrichment Score: 1.38

Count

P_Value

GOTERM_MF_FAT

substrate specific channel activity

21

3.40E-02

GOTERM_MF_FAT

channel activity

21

4.60E-02

GOTERM_MF_FAT

passive transmembrane transporter activity

21

4.70E-02