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Table 3 Clinical features

From: Allele-specific disparity in breast cancer

Grade
Status Grade I Grade II Grade III
Disparity (96273 loci) 79120 (5.9%) 485506 (9.3%) 494383 (12.6%)
No Disparity (96273 loci) 1268281 (94.1%) 4711144 (90.7%) 3451422 (87.4%)
Total 1347401 (100%) 5196650 (100%) 3945805 (100%)
p-value < 0.001, (Cochran-Armitage trend test = X-squared = 68885.98, df = 1)
ER
Status ER = neg ER = pos  
Disparity (96273 loci) 471696 (11.7%) 611716 (9.3%)  
No Disparity(96273 loci) 3570454 (88.3%) 5932211 (90.7%)  
Total 4042150 (100%) 6543927 (100%)  
p-value < 0.001, (Pearson's Chi-squared test, X-squared = 14659.47, df = 1)
HER2
Status HER2 = neg HER2 = pos  
Disparity (96273 loci) 820891 (10.4%) 191389 (9.9%)  
No Disparity(96273 loci) 7070289 (89.6%) 1733669 (90.1%)  
Total 7891180 (100%) 1925058 (100%)  
p-value < 0.001, (Pearson's Chi-squared test, X-squared = 14659.47, df = 1)
TP53
Status TP53 = wildtype TP53 = mutate  
Disparity (96273 loci) 607219 (8.2%) 483065 (14.3%)  
No Disparity(96273 loci) 6802862 (91.8%) 2885412 (85.7%)  
total 7410081 (100%) 3368477 (100%)  
p-value < 0.001, (Pearson's Chi-squared test, X-squared = 96216.44, df = 1)
PR
Status PR = neg PR = pos  
Disparity (96273 loci) 659139 (12%) 409458 (8.2%)  
No Disparity(96273 loci) 4826429 (88%) 4594835 (91.8%)  
Total 5485568 (100%) 5004293 (100%)  
p-value < 0.001, (Pearson's Chi-squared test, X-squared = 42038.96, df = 1)
  1. Distribution of the samples according to the clinical features such as grade, tumour size, ER, PR, HER2 status, breast cancer subtypes, and TP53 mutation status between the SNPs showing disparity and those not showing disparity.