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Table 4 Functions and canonical pathways as differentially expressed down-regulated genes in ob/ob vs. WT, with no significant changes in POKO vs. WT mice

From: Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass

Top Bio Functions   
Name p-value # Molecules
Diseases and Disorders   
Dermatological Diseases and Conditions 3.01E-05 - 4.21E-02 37
Genetic Disorder 3.01E-05 - 4.21E-02 91
Cancer 9.80E-05 - 4.21E-02 170
Developmental Disorder 6.95E-04 - 4.21E-02 11
Gastrointestinal Disease 1.48E-03 - 4.21E-02 71
Molecular and Cellular Functions   
Lipid Metabolism 4.46E-07 - 4.21E-02 50
Small Molecule Biochemistry 4.46E-07 - 4.21E-02 71
Vitamin and Mineral Metabolism 4.46E-07 - 4.21E-02 23
Cell-To-Cell Signaling and Interaction 1.48E-04 - 4.21E-02 63
Cellular Assembly and Organization 1.48E-04 - 4.21E-02 46
Physiological System Development and Function   
Tumor Morphology 9.80E-05 - 4.21E-02 22
Hair and Skin Development and Function 1.37E-03 - 4.21E-02 26
Organ Development 1.37E-03 - 4.18E-02 35
Digestive System Development and Function 1.50E-03 - 1.95E-02 11
Organismal Development 1.50E-03 - 4.18E-02 26
Top Canonical Pathways   
Name p-value Ratio
Biosynthesis of Steroids 1.96E-04 7/128(0.055)
HER-2 Signaling in Breast Cancer 3.41E-03 9/79 (0.114)
Tight Junction Signaling 9.59E-03 13/167 (0.078)
Fatty Acid Biosynthesis 1.23E-02 3/51 (0.059)
ERK5 Signaling 1.26E-02 7/71 (0.099)
  1. Functions and canonical pathways identified by IPA as differentially expressed down regulated genes in islets from ob/ob vs. WT mice (fold change ≥ 1; P ≤ 0.05), with no significant changes in islets from POKO vs. WT mice.
  2. Note: p-value was calculated using the Benjamini-Hochberg method of multiple testing correction. In the case of canonical pathways "Ratio" indicates the number of differentially expressed genes in a given pathway, divided by total number of genes that make up that pathway.