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Table 2 Correlation of mechanism-based candidate gene methylation levels with birth weight

From: DNA methylation differences at growth related genes correlate with birth weight: a molecular signature linked to developmental origins of adult disease?

Gene Symbol GoldenGate CpG ID GoldenGate Methylation vs. Birth Weight % (R2) Infinium CpG ID Infinium Methylation vs. Birth Weight % (R2)
   Cord Blood (n = 22) Placenta (n = 23)   Cord Blood (n = 48) Placenta (n = 48)
IGF1 cg17084217 0.004 0.004 cg01305421 0.005 0.007
  cg25163611 1.0E-04 0.031 cg14568338   
IGF1R cg19714640 0.097 0.038 cg22375192 0.011 0.021
  cg20742855 0.005 0.018 cg02166532 0.006 0.001
IGF2 cg10649864 0.007 0.077 cg02807948 0.049 4.0E-04
  cg17626526 0.040 0.026 cg13756879 4.0E-04 0.001
  cg17084217 0.011 3.0E-04 cg20339650 0.014 4.0E-04
     cg22956483 3.0E-04 0.001
     cg01305421 0.032 0.003
IGF2BP1   n/a n/a cg06638433 0.005 0.044
     cg13877465 0.019 8.3E-05
IGF2BP2   n/a n/a cg18234011 0.005 0.024
     cg24450631 0.005 0.006
IGF2BP3 cg00508334 3.5E-05 0.028 cg02860543 0.049 1.2E-05
  cg21413760 0.062 3.1E-07 cg19042950 1.2E-05 0.002
IGF2R cg07148501 0.009 0.076 cg00230368 0.007 0.014
  cg12721534 0.014 0.063 cg14556618 8.4E-05 1.0E-04
IGFBP1 cg20666158 0.015 0.059 cg05660795 0.033 0.014
  cg23864854 0.048 0.028 cg27447599 0.021 0.018
IGFBP2 cg07828219 0.032 0.018 cg25854162 0.004 0.011
  cg17207942 0.035 0.001 cg26187237 6.7E-05 0.015
IGFBP3 cg12826145 0.023 0.012 cg04796162 0.014 0.036
  cg14625938 0.001 0.010 cg06713098 0.027 0.002
     cg08831744 0.001 0.003
     cg15898840 0.026 0.003
     cg22083798 0.029 0.042
IGFBP4 cg03940014 0.054 0.008 cg00512374 0.008 0.022
  cg22392383 0.018 0.042    
IGFBP5 cg20419545 0.066 0.001 cg19008649 0.021 0.005
  cg24617085 0.067 0.017 cg22467567 0.001 0.006
IGFBP6 cg00122038 0.009 0.011 cg01773854 0.051 1.0E-04
  cg22732012 0.072 2.0E-04 cg08629913 0.024 0.003
IGFBP7 cg00431950 0.023 0.037 cg00884221 0.002 0.001
  cg16546204 0.026 0.014 cg03876618 3.3E-05 0.001
INS cg13349859 0.001 0.020 cg00613255 0.001 0.005
  cg14426263 0.008 0.005 cg03366382 1.0E-04 0.044
     cg13993218 0.003 0.012
     cg25336198 0.005 0.008
INSR cg05427477 0.002 0.084 cg01263716 n/a n/a
  cg19110381 0.072 0.001 cg01505590   
PHLDA2 cg03637064 0.019 0.163 cg04720330 4.0E-05 0.062
  cg18242686 0.024 0.006 cg11961618 0.039 0.014
     cg14415214 0.001 0.081
     cg21259253 4.0E-04 0.031
     cg26799802 3.0E-04 0.035
     cg00702231 0.019 0.031
     cg07077459 0.055 0.006
PLAGL1 cg10923987 0.002 0.052 cg08263357 3.8E-06 0.006
  cg12757684 0.067 0.062 cg12757684 0.001 0.013
     cg14161241 0.002 0.030
     cg17895149 0.001 0.009
     cg22378065 0.017 0.034
     cg25350411 0.002 0.001
     cg00613255 0.007 0.003
     cg03366382 0.010 0.001
IGF2/H19* cg25871270 0.001 0.065   n/a n/a
  cg19731870 0.002 0.008    
  1. Multiple entries represent data from multiple CpG sites. The best correlation obtained in each group is shown in bold
  2. * IGF2/H19 differentially methylated region (DMR)
  3. n/a = not applicable i.e. no probes on array