DNA methylation differences at growth related genes correlate with birth weight: a molecular signature linked to developmental origins of adult disease?

Turan, Nahid; Ghalwash, Mohamed F; Katari, Sunita; Coutifaris, Christos; Obradovic, Zoran; Sapienza, Carmen

doi:10.1186/1755-8794-5-10

Table 2 Correlation of mechanism-based candidate gene methylation levels with birth weight

From: DNA methylation differences at growth related genes correlate with birth weight: a molecular signature linked to developmental origins of adult disease?

Gene Symbol	GoldenGate CpG ID	GoldenGate Methylation vs. Birth Weight % (R²)		Infinium CpG ID	Infinium Methylation vs. Birth Weight % (R²)
		Cord Blood (n = 22)	Placenta (n = 23)		Cord Blood (n = 48)	Placenta (n = 48)
*IGF1*	cg17084217	0.004	0.004	cg01305421	0.005	0.007
	cg25163611	1.0E-04	0.031	cg14568338
*IGF1R*	cg19714640	0.097	0.038	cg22375192	0.011	0.021
	cg20742855	0.005	0.018	cg02166532	0.006	0.001
*IGF2*	cg10649864	0.007	0.077	cg02807948	0.049	4.0E-04
	cg17626526	0.040	0.026	cg13756879	4.0E-04	0.001
	cg17084217	0.011	3.0E-04	cg20339650	0.014	4.0E-04
				cg22956483	3.0E-04	0.001
				cg01305421	0.032	0.003
*IGF2BP1*		n/a	n/a	cg06638433	0.005	0.044
				cg13877465	0.019	8.3E-05
*IGF2BP2*		n/a	n/a	cg18234011	0.005	0.024
				cg24450631	0.005	0.006
*IGF2BP3*	cg00508334	3.5E-05	0.028	cg02860543	0.049	1.2E-05
	cg21413760	0.062	3.1E-07	cg19042950	1.2E-05	0.002
*IGF2R*	cg07148501	0.009	0.076	cg00230368	0.007	0.014
	cg12721534	0.014	0.063	cg14556618	8.4E-05	1.0E-04
*IGFBP1*	cg20666158	0.015	0.059	cg05660795	0.033	0.014
	cg23864854	0.048	0.028	cg27447599	0.021	0.018
*IGFBP2*	cg07828219	0.032	0.018	cg25854162	0.004	0.011
	cg17207942	0.035	0.001	cg26187237	6.7E-05	0.015
*IGFBP3*	cg12826145	0.023	0.012	cg04796162	0.014	0.036
	cg14625938	0.001	0.010	cg06713098	0.027	0.002
				cg08831744	0.001	0.003
				cg15898840	0.026	0.003
				cg22083798	0.029	0.042
*IGFBP4*	cg03940014	0.054	0.008	cg00512374	0.008	0.022
	cg22392383	0.018	0.042
*IGFBP5*	cg20419545	0.066	0.001	cg19008649	0.021	0.005
	cg24617085	0.067	0.017	cg22467567	0.001	0.006
*IGFBP6*	cg00122038	0.009	0.011	cg01773854	0.051	1.0E-04
	cg22732012	0.072	2.0E-04	cg08629913	0.024	0.003
*IGFBP7*	cg00431950	0.023	0.037	cg00884221	0.002	0.001
	cg16546204	0.026	0.014	cg03876618	3.3E-05	0.001
*INS*	cg13349859	0.001	0.020	cg00613255	0.001	0.005
	cg14426263	0.008	0.005	cg03366382	1.0E-04	0.044
				cg13993218	0.003	0.012
				cg25336198	0.005	0.008
*INSR*	cg05427477	0.002	0.084	cg01263716	n/a	n/a
	cg19110381	0.072	0.001	cg01505590
*PHLDA2*	cg03637064	0.019	0.163	cg04720330	4.0E-05	0.062
	cg18242686	0.024	0.006	cg11961618	0.039	0.014
				cg14415214	0.001	0.081
				cg21259253	4.0E-04	0.031
				cg26799802	3.0E-04	0.035
				cg00702231	0.019	0.031
				cg07077459	0.055	0.006
*PLAGL1*	cg10923987	0.002	0.052	cg08263357	3.8E-06	0.006
	cg12757684	0.067	0.062	cg12757684	0.001	0.013
				cg14161241	0.002	0.030
				cg17895149	0.001	0.009
				cg22378065	0.017	0.034
				cg25350411	0.002	0.001
				cg00613255	0.007	0.003
				cg03366382	0.010	0.001
IGF2/H19*	cg25871270	0.001	0.065		n/a	n/a
	cg19731870	0.002	0.008

Multiple entries represent data from multiple CpG sites. The best correlation obtained in each group is shown in bold
* IGF2/H19 differentially methylated region (DMR)
n/a = not applicable i.e. no probes on array

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ISSN: 1755-8794

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