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Table 5 Correlation between DNA methylation and transcription in the candidate genes

From: DNA methylation differences at growth related genes correlate with birth weight: a molecular signature linked to developmental origins of adult disease?

Tissue Methylation Candidate CpG ID Gene Transcript Transcript ID Correlation1 Pvalue
Blood MSX1 cg14167596 APOE ILMN_1740938 0.76 < 0.001
   cg11930592 ATP6AP1 ILMN_1697694 0.32 0.03
   cg15755084    0.32 0.03
   cg20891301a    -0.302 0.04
   cg26615830    0.32 0.03
   cg15696627    0.44 0.002
   cg03717979    0.51 < 0.001
   cg15755084 PRSS21 ILMN_2382964 -0.38 0.01
   cg15696627    -0.37 0.01
   cg20588069    -0.42 0.003
   cg06677140    -0.29 0.04
   cg09573795   ILMN_1774256 -0.34 0.02
   cg03199651    -0.30 0.04
   cg20588069    -0.36 0.01
   cg22609784    -0.31 0.03
   cg15696627 RCOR1 ILMN_1743421 -0.28 0.05
   cg03717979   ILMN_1743421 -0.29 0.04
   cg06677140   ILMN_1743421 -0.38 0.01
Placenta CDK2 cg09106999 GRB10 ILMN_1667771 -0.323 0.03
   cg00129774   ILMN_1669617 0.51 < 0.001
   cg00129774   ILMN_2340919 0.46 0.001
   cg04108502    0.37 0.01
   cg09304040 PGRMC1 ILMN_1684771 -0.34 0.02
   cg09106999 RGS14 ILMN_1696828 -0.31 0.03
  EVPL cg24697031 EVPL ILMN_1727288 -0.30 0.04
  GRB10 cg20651681 CDK2 ILMN_1653443 -0.29 0.04
   cg15774495    -0.28 0.05
   cg06790324    -0.36 0.01
   cg06386517 GRB10 ILMN_1669617 0.34 0.02
   cg20651681    0.39 0.01
   cg06790324    0.29 0.04
   cg03104936    0.29 0.05
   cg03104936   ILMN_1652662 0.37 0.01
   cg06386517   ILMN_2340919 0.33 0.02
   cg20651681    0.34 0.02
   cg24183958    0.38 0.01
   cg06790324    0.39 0.01
   cg20651681 PGRMC1 ILMN_1684771 -0.30 0.04
   cg03104936    -0.29 0.05
   cg20651681 RGS14 ILMN_1696828 -0.34 0.02
  NAT8L cg08211091 GRB10 ILMN_1669617 -0.31 0.03
  1. 1 Pearson correlation coefficient
  2. 2 MSX1 has five CpGs that are positively correlated with ATP6AP1, however, cg20891301, which is anomalously negatively correlated is located at the end of the CpG island
  3. 3 CDK2 has three CpGs that are positively correlated with GRB10, however, one CpG, cg09106999 is negatively correlated
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BMC Medical Genomics

ISSN: 1755-8794

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