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Table 5 Correlation between DNA methylation and transcription in the candidate genes

From: DNA methylation differences at growth related genes correlate with birth weight: a molecular signature linked to developmental origins of adult disease?

Tissue

Methylation Candidate

CpG ID

Gene Transcript

Transcript ID

Correlation1

Pvalue

Blood

MSX1

cg14167596

APOE

ILMN_1740938

0.76

< 0.001

  

cg11930592

ATP6AP1

ILMN_1697694

0.32

0.03

  

cg15755084

  

0.32

0.03

  

cg20891301a

  

-0.302

0.04

  

cg26615830

  

0.32

0.03

  

cg15696627

  

0.44

0.002

  

cg03717979

  

0.51

< 0.001

  

cg15755084

PRSS21

ILMN_2382964

-0.38

0.01

  

cg15696627

  

-0.37

0.01

  

cg20588069

  

-0.42

0.003

  

cg06677140

  

-0.29

0.04

  

cg09573795

 

ILMN_1774256

-0.34

0.02

  

cg03199651

  

-0.30

0.04

  

cg20588069

  

-0.36

0.01

  

cg22609784

  

-0.31

0.03

  

cg15696627

RCOR1

ILMN_1743421

-0.28

0.05

  

cg03717979

 

ILMN_1743421

-0.29

0.04

  

cg06677140

 

ILMN_1743421

-0.38

0.01

Placenta

CDK2

cg09106999

GRB10

ILMN_1667771

-0.323

0.03

  

cg00129774

 

ILMN_1669617

0.51

< 0.001

  

cg00129774

 

ILMN_2340919

0.46

0.001

  

cg04108502

  

0.37

0.01

  

cg09304040

PGRMC1

ILMN_1684771

-0.34

0.02

  

cg09106999

RGS14

ILMN_1696828

-0.31

0.03

 

EVPL

cg24697031

EVPL

ILMN_1727288

-0.30

0.04

 

GRB10

cg20651681

CDK2

ILMN_1653443

-0.29

0.04

  

cg15774495

  

-0.28

0.05

  

cg06790324

  

-0.36

0.01

  

cg06386517

GRB10

ILMN_1669617

0.34

0.02

  

cg20651681

  

0.39

0.01

  

cg06790324

  

0.29

0.04

  

cg03104936

  

0.29

0.05

  

cg03104936

 

ILMN_1652662

0.37

0.01

  

cg06386517

 

ILMN_2340919

0.33

0.02

  

cg20651681

  

0.34

0.02

  

cg24183958

  

0.38

0.01

  

cg06790324

  

0.39

0.01

  

cg20651681

PGRMC1

ILMN_1684771

-0.30

0.04

  

cg03104936

  

-0.29

0.05

  

cg20651681

RGS14

ILMN_1696828

-0.34

0.02

 

NAT8L

cg08211091

GRB10

ILMN_1669617

-0.31

0.03

  1. 1 Pearson correlation coefficient
  2. 2 MSX1 has five CpGs that are positively correlated with ATP6AP1, however, cg20891301, which is anomalously negatively correlated is located at the end of the CpG island
  3. 3 CDK2 has three CpGs that are positively correlated with GRB10, however, one CpG, cg09106999 is negatively correlated