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Table 2 Association of apoptosis SNPs with prostate cancer

From: Interaction among apoptosis-associated sequence variants and joint effects on aggressive prostate cancer

Marker (Alleles
and position)
Allele Cases N (%) Controls N (%) OR (95%CI) Adj OR (95%CI)* p value Bonf.
p value
p trend Permut.
p value
BIK AA 944 (81.2) 855 (77.0) 1.00 (reference) 1.00 (reference) 0.048 1.000 0.017 1.000
rs4988366 AG 208 (17.9) 244 (22.0) 0.77 (0.63-0.95) 0.78 (0.63-0.96) 0.014    
A41830193G GG 12 (1.0) 14 (1.3) 0.78 (0.36-1.69) 0.79 (0.36-1.71) 0.523    
  AG + GG 220 (18.9) 258 (23.2) 0.78 (0.63-0.95) 0.78 (0.64-0.96) 0.014 1.000   0.831
BNIP3L CC 556 (47.8) 477 (42.9) 1.00 (reference) 1.00 (reference) 0.041 1.000 0.012 0.998
rs10503786 TC 480 (41.3) 489 (44.0) 0.84 (0.71-1.00) 0.85 (0.71-1.01) 0.055    
C26325853T TT 103 (8.9) 122 (11.0) 0.72 (0.54-0.97) 0.73 (0.55-0.98) 0.029    
  TC + TT 583 (50.1) 611 (55.0) 0.82 (0.70-0.97) 0.82 (0.70-0.97) 0.020 1.000   0.928
CASP9 CC 320 (27.5) 348 (31.3) 1.00 (reference) 1.00 (reference) 0.075 1.000 0.023 1.000
rs1052571 TC 589 (50.6) 553 (49.8) 0.88 (0.71-1.10) 0.88 (0.71-1.09) 0.265    
C15595919T TT 253 (21.8) 210 (18.9) 0.76 (0.60-0.97) 0.75 (0.59-0.95) 0.026    
  TC + CC 842 (72.4) 763 (68.7) 0.84 (0.68-1.03) 0.83 (0.68-1.02) 0.090 1.000   0.998
IKBKE CC 837 (72.0) 740 (66.6) 1.00 (reference) 1.00 (reference) 0.017 1.000 0.005 0.903
rs1539243 TC 291 (25.0) 325 (29.3) 0.79 (0.66-0.95) 0.78 (0.65-0.95) 0.014    
C203036182T TT 36 (3.1) 47 (4.2) 0.68 (0.43-1.06) 0.68 (0.43-1.06) 0.086    
  TC + TT 327 (28.1) 372 (33.5) 0.78 (0.65-0.93) 0.77 (0.64-0.92) 0.006 0.943   0.522
PRKCE TT 841 (72.3) 788 (70.9) 1.00 (reference) 1.00 (reference) 0.030 1.000 0.139 0.987
rs608139 TC 304 (26.1) 288 (25.9) 0.99 (0.82-1.19) 0.98 (0.51-1.19) 0.909    
T45789207C CC 18 (1.5) 36 (3.2) 0.47 (0.26-0.83) 0.50 (0.28-0.88) 0.010    
  TC + CC 322 (27.7) 324 (29.2) 0.93 (0.78-1.12) 0.93 (0.78-1.12) 0.435 1.000   1.000
PRKCE AA 556 (47.8) 482 (43.4) 1.00 (reference) 1.00 (reference) 0.045 1.000 0.013 1.000
rs935673 AG 503 (43.3) 503 (45.3) 0.87 (0.73-1.03) 0.87 (0.73-1.04) 0.107    
A46034008G GG 105 (9.0) 128 (11.5) 0.71 (0.53-0.95) 0.71 (0.53-0.95) 0.019    
  AG + GG 608 (52.3) 631 (56.8) 0.84 (0.71-0.99) 0.84 (0.71-0.99) 0.034 1.000   0.991
TNFRSF10B GG 547 (47.0) 537 (48.3) 1.00 (reference) 1.00 (reference) 0.055 1.000 0.253 1.000
rs1001793 AG 448 (38.5) 458 (41.2) 0.96 (0.80-1.15) 0.96 (0.80-1.14) 0.653    
G22956894A AA 131 (11.3) 93 (8.4) 1.38 (1.03-1.85) 1.38 (1.03-1.85) 0.029    
  AG + AA 579 (49.8) 551 (49.6) 1.01 (0.86-1.19) 1.03 (0.87-1.22) 0.892 1.000   1.000
TNFRSF1A AA 375 (32.2) 376 (33.8) 1.00 (reference) 1.00 (reference) 0.079 1.000 0.070 1.000
rs4149576 AG 545 (46.9) 545 (79.1) 0.78 (0.62-0.98) 0.79 (0.63-0.99) 0.034    
A6319376G GG 234 (20.1) 183 (16.5) 0.78 (0.61-0.99) 0.79 (0.62-1.01) 0.043    
  AG + GG 779 (67.0) 728 (65.5) 0.78 (0.63-0.97) 0.79 (0.63-0.98) 0.024 1.000   0.854
TNFRSF1A TT 326 (28.0) 270 (24.3) 1.00 (reference) 1.00 (reference) 0.087 1.000 0.205 1.000
rs4149577 TC 571 (49.1) 591 (5302) 0.80 (0.66-0.98) 0.80 (0.66-0.98) 0.027    
T6317783C CC 265 (22.8) 251 (22.6) 0.87 (0.69-1.11) 0.88 (0.70-1.12) 0.266    
  TC + CC 836 (71.9) 842 (75.8) 0.82 (0.68-0.99) 0.83 (0.68-1.00) 0.038 1.000   0.141
TNFSF10 GG 630 (54.2) 668 (60.1) 1.00 (reference) 1.00 (reference) 0.026 1.000 0.014 0.977
rs4894559 AG 456 (39.2) 380 (34.2) 1.27 (1.07-1.51) 1.27 (1.06-1.51) 0.007    
G173716071A AA 76 (6.5) 65 (5.9) 1.24 (0.88-1.78) 1.23 (0.87-1.74) 0.227    
  AG + AA 532 (45.7) 445 (40.1) 1.26 (1.06-1.49) 1.26 (1.07-1.49) 0.007 1.000   0.594
  1. Abbreviations: Bonf., Bonferroni; Permut., Permutation; *adjusted for age and family history of PCA