Table 2 Association of apoptosis SNPs with prostate cancer
Marker (Alleles and position) | Allele | Cases N (%) | Controls N (%) | OR (95%CI) | Adj OR (95%CI)* | p value | Bonf. p value | p trend | Permut. p value |
|---|---|---|---|---|---|---|---|---|---|
BIK | AA | 944 (81.2) | 855 (77.0) | 1.00 (reference) | 1.00 (reference) | 0.048 | 1.000 | 0.017 | 1.000 |
rs4988366 | AG | 208 (17.9) | 244 (22.0) | 0.77 (0.63-0.95) | 0.78 (0.63-0.96) | 0.014 | Â | Â | Â |
A41830193G | GG | 12 (1.0) | 14 (1.3) | 0.78 (0.36-1.69) | 0.79 (0.36-1.71) | 0.523 | Â | Â | Â |
| Â | AG + GG | 220 (18.9) | 258 (23.2) | 0.78 (0.63-0.95) | 0.78 (0.64-0.96) | 0.014 | 1.000 | Â | 0.831 |
BNIP3L | CC | 556 (47.8) | 477 (42.9) | 1.00 (reference) | 1.00 (reference) | 0.041 | 1.000 | 0.012 | 0.998 |
rs10503786 | TC | 480 (41.3) | 489 (44.0) | 0.84 (0.71-1.00) | 0.85 (0.71-1.01) | 0.055 | Â | Â | Â |
C26325853T | TT | 103 (8.9) | 122 (11.0) | 0.72 (0.54-0.97) | 0.73 (0.55-0.98) | 0.029 | Â | Â | Â |
| Â | TC + TT | 583 (50.1) | 611 (55.0) | 0.82 (0.70-0.97) | 0.82 (0.70-0.97) | 0.020 | 1.000 | Â | 0.928 |
CASP9 | CC | 320 (27.5) | 348 (31.3) | 1.00 (reference) | 1.00 (reference) | 0.075 | 1.000 | 0.023 | 1.000 |
rs1052571 | TC | 589 (50.6) | 553 (49.8) | 0.88 (0.71-1.10) | 0.88 (0.71-1.09) | 0.265 | Â | Â | Â |
C15595919T | TT | 253 (21.8) | 210 (18.9) | 0.76 (0.60-0.97) | 0.75 (0.59-0.95) | 0.026 | Â | Â | Â |
| Â | TC + CC | 842 (72.4) | 763 (68.7) | 0.84 (0.68-1.03) | 0.83 (0.68-1.02) | 0.090 | 1.000 | Â | 0.998 |
IKBKE | CC | 837 (72.0) | 740 (66.6) | 1.00 (reference) | 1.00 (reference) | 0.017 | 1.000 | 0.005 | 0.903 |
rs1539243 | TC | 291 (25.0) | 325 (29.3) | 0.79 (0.66-0.95) | 0.78 (0.65-0.95) | 0.014 | Â | Â | Â |
C203036182T | TT | 36 (3.1) | 47 (4.2) | 0.68 (0.43-1.06) | 0.68 (0.43-1.06) | 0.086 | Â | Â | Â |
| Â | TC + TT | 327 (28.1) | 372 (33.5) | 0.78 (0.65-0.93) | 0.77 (0.64-0.92) | 0.006 | 0.943 | Â | 0.522 |
PRKCE | TT | 841 (72.3) | 788 (70.9) | 1.00 (reference) | 1.00 (reference) | 0.030 | 1.000 | 0.139 | 0.987 |
rs608139 | TC | 304 (26.1) | 288 (25.9) | 0.99 (0.82-1.19) | 0.98 (0.51-1.19) | 0.909 | Â | Â | Â |
T45789207C | CC | 18 (1.5) | 36 (3.2) | 0.47 (0.26-0.83) | 0.50 (0.28-0.88) | 0.010 | Â | Â | Â |
| Â | TC + CC | 322 (27.7) | 324 (29.2) | 0.93 (0.78-1.12) | 0.93 (0.78-1.12) | 0.435 | 1.000 | Â | 1.000 |
PRKCE | AA | 556 (47.8) | 482 (43.4) | 1.00 (reference) | 1.00 (reference) | 0.045 | 1.000 | 0.013 | 1.000 |
rs935673 | AG | 503 (43.3) | 503 (45.3) | 0.87 (0.73-1.03) | 0.87 (0.73-1.04) | 0.107 | Â | Â | Â |
A46034008G | GG | 105 (9.0) | 128 (11.5) | 0.71 (0.53-0.95) | 0.71 (0.53-0.95) | 0.019 | Â | Â | Â |
| Â | AG + GG | 608 (52.3) | 631 (56.8) | 0.84 (0.71-0.99) | 0.84 (0.71-0.99) | 0.034 | 1.000 | Â | 0.991 |
TNFRSF10B | GG | 547 (47.0) | 537 (48.3) | 1.00 (reference) | 1.00 (reference) | 0.055 | 1.000 | 0.253 | 1.000 |
rs1001793 | AG | 448 (38.5) | 458 (41.2) | 0.96 (0.80-1.15) | 0.96 (0.80-1.14) | 0.653 | Â | Â | Â |
G22956894A | AA | 131 (11.3) | 93 (8.4) | 1.38 (1.03-1.85) | 1.38 (1.03-1.85) | 0.029 | Â | Â | Â |
| Â | AG + AA | 579 (49.8) | 551 (49.6) | 1.01 (0.86-1.19) | 1.03 (0.87-1.22) | 0.892 | 1.000 | Â | 1.000 |
TNFRSF1A | AA | 375 (32.2) | 376 (33.8) | 1.00 (reference) | 1.00 (reference) | 0.079 | 1.000 | 0.070 | 1.000 |
rs4149576 | AG | 545 (46.9) | 545 (79.1) | 0.78 (0.62-0.98) | 0.79 (0.63-0.99) | 0.034 | Â | Â | Â |
A6319376G | GG | 234 (20.1) | 183 (16.5) | 0.78 (0.61-0.99) | 0.79 (0.62-1.01) | 0.043 | Â | Â | Â |
| Â | AG + GG | 779 (67.0) | 728 (65.5) | 0.78 (0.63-0.97) | 0.79 (0.63-0.98) | 0.024 | 1.000 | Â | 0.854 |
TNFRSF1A | TT | 326 (28.0) | 270 (24.3) | 1.00 (reference) | 1.00 (reference) | 0.087 | 1.000 | 0.205 | 1.000 |
rs4149577 | TC | 571 (49.1) | 591 (5302) | 0.80 (0.66-0.98) | 0.80 (0.66-0.98) | 0.027 | Â | Â | Â |
T6317783C | CC | 265 (22.8) | 251 (22.6) | 0.87 (0.69-1.11) | 0.88 (0.70-1.12) | 0.266 | Â | Â | Â |
| Â | TC + CC | 836 (71.9) | 842 (75.8) | 0.82 (0.68-0.99) | 0.83 (0.68-1.00) | 0.038 | 1.000 | Â | 0.141 |
TNFSF10 | GG | 630 (54.2) | 668 (60.1) | 1.00 (reference) | 1.00 (reference) | 0.026 | 1.000 | 0.014 | 0.977 |
rs4894559 | AG | 456 (39.2) | 380 (34.2) | 1.27 (1.07-1.51) | 1.27 (1.06-1.51) | 0.007 | Â | Â | Â |
G173716071A | AA | 76 (6.5) | 65 (5.9) | 1.24 (0.88-1.78) | 1.23 (0.87-1.74) | 0.227 | Â | Â | Â |
| Â | AG + AA | 532 (45.7) | 445 (40.1) | 1.26 (1.06-1.49) | 1.26 (1.07-1.49) | 0.007 | 1.000 | Â | 0.594 |