Table 2 Performance characteristics of NGAL and resistin as biomarkers of SBI, singly, and in combination with procalcitonin
Marker | Threshold | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | LR+ | LR- |
|---|---|---|---|---|---|---|---|
NGAL | 100 | 86.7 (83.2-90.2) | 50.0 (44.8-55.1) | 78.7 (74.4-82.9) | 63.9 (58.9-68.9) | 1.735 | 0.265 |
Resistin | 80 | 91.4 (88.4-94.3) | 51.9 (46.6-57.0) | 84.1 (80.4-87.9) | 68.3 (63.5-73.1) | 1.898 | 0.166 |
In combination with Procalcitonin: | |||||||
PCTNGALResistin | 2 100 80 | 82.7 (76.6-88.8) | 76.7 (69.9-83.5) | 89.6 (84.6-94.5) | 64.7 (57.0-72.4) | 3.556 | 0.226 |
PCTNGALResistin | 1 80 80 | 86.6 (78.8-90.4) | 72.1 (64.8-79.3) | 88.0 (82.7-93.2) | 66.0 (58.3-73.6) | 3.032 | 0.213 |