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Table 2 Performance characteristics of NGAL and resistin as biomarkers of SBI, singly, and in combination with procalcitonin

From: Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children

Marker Threshold Sensitivity
(95% CI)
Specificity
(95% CI)
PPV
(95% CI)
NPV (95% CI) LR+ LR-
NGAL 100 86.7 (83.2-90.2) 50.0 (44.8-55.1) 78.7 (74.4-82.9) 63.9 (58.9-68.9) 1.735 0.265
Resistin 80 91.4 (88.4-94.3) 51.9 (46.6-57.0) 84.1 (80.4-87.9) 68.3 (63.5-73.1) 1.898 0.166
In combination with Procalcitonin:
PCTNGALResistin 2
100
80
82.7 (76.6-88.8) 76.7 (69.9-83.5) 89.6 (84.6-94.5) 64.7 (57.0-72.4) 3.556 0.226
PCTNGALResistin 1
80
80
86.6 (78.8-90.4) 72.1 (64.8-79.3) 88.0 (82.7-93.2) 66.0 (58.3-73.6) 3.032 0.213
  1. PPV = positive predictive value, NPV = negative predictive value, LR + = likelihood ratio for a positive result, LR- = likelihood ratio for a negative result.