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Table 2 Ingenuity analysis of genes concordantly expressed between DC- and PF-fibroblasts but significantly different in CT

From: Fibroblasts from phenotypically normal palmar fascia exhibit molecular profiles highly similar to fibroblasts from active disease in Dupuytren's Contracture

ID Molecules Score Focus Molecules Top Functions Canonical Pathways
1 ABCG5, Ap1, BIRC3, CASP1, Caspase, CCR6, Creb, CSF2RA (includes EG:1438), DAPP1, DDOST, DMC1, ERK1/2, HNRNPU, IL1, IL18, IL12 (complex), IL17RD, Jnk, LEP, MECOM, NAPB, NFkB (complex), PDGF BB, PNPT1, RAD51, RNF31, SLC12A4, SSTR2, STAT5a/b, SUMO1, TNFSF14, TNFSF15, TP53BP2, UNC5B, XRCC2 47 25 Cell Cycle, DNA Replication, Recombination, and Repair, Metabolic Disease Pyrimidine Metabolism, Artherosclerosis Signaling, TREM1 Signaling, Glycosphingolipid Biosynthesis-Lactoseries, Death Receptor Signaling, Nucleotide Sugars Metabolism, Aminosugars Metabolism, LXR/RXR Activation, Axonal Guidance Signaling, FXR/RXR Activation, Amyotrophic Lateral Sclerosis Signaling, Endothelin-1 Signaling, N-Glycan Degradation, Cholecystokinin/Gastrin-mediated Signaling, p38 MAPK Signaling, Glycosaminoglycan Degradation, T Helper Cell Differentiation, Graft-versus-Host Disease Signaling, Ovarian Cancer Signaling, Chondroitin Sulfate Biosynthesis, Role of Cytokines in Mediating Communication between Immune Cells, Lymphotoxin β Receptor Signaling, Role of BRCA1 in DNA Damage Response, Dendritic Cell Maturation, Induction of Apoptosis by HIV1, IL-10 Signaling, JAK/STAT Signaling, GM-CSF Signaling, Hypoxia Signaling in the Cardiovascular System, Communication between Innate and Adaptive Immune Cells, Antiproliferative Role of Somatostatin Receptor 2, Linoleic Acid Metabolism, Acute Phase Response Signaling, Acute Myeloid Leukemia Signaling, leptin Signaling in Obesity, Altered T Cell and B Cell Signaling in Rheumatoid Arthritis, Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses, PPAR Signaling, Apoptosis Signaling, IL-6 Signaling, Crosstalk between Dendritic Cells and Natural Killer Cells, p53 Signaling, Chronic Myeloid Leukemia Signaling,
2 ACTR3, ACVR2A, ADCY, AHR, Akt, CAPZA1, CHRNA5, Ck2, CTDP1, ERK, FLNC, FSH, ganglioside GD1b, GATA6, hCG, Histone h3, Histone h4, HSD17B7, Lh, MAGT1, Mapk, MIR124, NELF, NME2, P38 MAPK, PI3K, Pka, PPIB, PROS1, RNA polymerase II, SNAPC4, STAR, STMN1, UPP1, USP49 33 19 DNA Replication, Recombination, and Repair, Drug Metabolism, Endocrine System Development and Function Pyrimidine Metabolism, Purine Metabolism, N-Glycan Biosynthesis, Axonal Guidance Signaling, Androgen and Estrogen Metabolism, Factors Promoting Cardiogenesis in Vertebrates, Coagulation System, RhoA Signaling, Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency, AMPK Signaling, Estrogen-Dependent Breast Signaling, Activation of IRF by Cytosolic Pattern Recognition Receptors, Wnt/β-catenin Signaling, Caveolar-mediated Endocytosis Signaling, Ephrin Recpetor Signaling, NRF2-mediated Oxidative Stress Response, TGF-β Signaling, Protein Ubiquitination Pathway, Thrombin Signaling, Regulation of Actin-based Motility by Rho, Virus Entry via Endocytic Pathways, Fcy Receptor-mediated Phagocytosis in Macrophages and Monocytes
3 C10ORF58, C6ORF170, CCNB2, CDC7, CPSF4, FBXL12, FCAR, FKBP11, GADD45B, IL9, IL24, Il12 receptor, ITIH3, ITIH5, ITPA, KIAA0101, MAN2B2 (includes EG:23324), MARK3, MCART1, NFYB, PCNA, PFN2, PGRMC1, PILRA, POLD1, PTGS1, RORA, RRAD, STAT4, TBX21, TERT, TGFB1, TGFBR2, XBP1, ZNF394 22 14 Cellular Development, Cell Morphology, Cell-Mediated Immune Response Pyrimidine Metabolism, Purine Metabolism, Cleavage and Polyadenylation of Pre-mRNA, Eicosanoid Signaling, Endothelin-1 Signaling, N-Glycan Degradation, Arachidonic Acid Metabolism, Ovarian Cancer Signaling,
4 Amino acids, BACE1, BLZF1, C1D, CBR3, CCAR1, CDC6, COL4A3BP, CSNK1G2, EXO1, FEN1, GSTA5, HNF4A, MCM4, MCM5, MCM6, MCM8, MEG3 (includes EG:55384), MLH1, MST1, PMM1, PPARG, PPP1R15B, PRKY, PTGR2, RAB2A, RORC, SAP30BP, SFRS11, SORBS1, STK16, TEAD3, TP53, VDAC2, XPNPEP3 21 14 Tumor Morphology, Cancer, Cell Cycle Wnt/β-catenin Signaling, Inositol Metabolism,
5 C12ORF24, C3ORF34, C4ORF43, CBR3, CDKN2AIPNL, CEBPB, CYP1A1, D-glucose, DAG1, DCAF13, ETFDH, F7, FKTN, HNF1A, HNF4A, IL1B, INS, LRSAM1, MAPK8, NCK1, NFkB (complex), PHF23, POFUT1, PRR3, SESN2, SLC25A32, SP1, SRC, TSG101, UBE2D3 (includes EG:7323), UBE2N, ZNF557, ZNF577 20 13 Carbohydrate Metabolism, Molecular Transport, Small Molecule Biochemistry  
6 ATP, BACE1, C14ORF153, CASP3, CRCP, CTSD, EEF2, EIF2AK3, ERBB2, EREG, ERP29, FUT3, GALNT3, ganglioside GD1a, GHR, GRIPAP1, HIVEP2, HLA-DRA, HRAS, IL24, MSH2, MYO9B, N4BP2, NLRP3, ODZ3, PPP1R15A (includes EG:23645), PRTN3, RFX4, RFXANK, Rsk, SERPINE2, Shc, Sod, SULT1A1, TNF 19 13 Cellular Assembly and Organization, Tissue Morphology, Cell Death Pyrimidine Metabolism, Purine Metabolism, Cysteine Metabolism, Glycosphingolipid Biosynthesis-Lactoseries, Sulfur Metabolism, Glycosphingolipid Biosynthesis-Neolactoseries, O-Glycan Biosynthesis, Keratan Sulfate Biosynthesis, Chondroitin Sulfate Biosynthesis, BMP Signaling Pathway, NRF2-mediated Oxidative Stress Response, EIF2 Signaling
7 C9ORF80, CDC45L, CTSD, DEFB1, EEF2, Eotaxin, ERAP2, GADD45B, GHR, GRM8, HMGA1, IFNB1, IFNG, IRF9, LILRB3 (includes EG:11025), LIMK1, LMNB2, MSH2, MSH3, MYC, ORC1L, ORC2L, ORC6L, PHC2, PNPT1, RHOB, Rock, ROCK2, RPL7, SEPHS2, SERPING1, STK11, TLE1, TMEM70, UTY 18 12 Cell Cycle, Gene Expression, Inflammatory Response Pyrimidine Metabolism, Nucleotide Sugars Metabolism, Aminosugars Metabolism, Axonal Guidance Signaling, Cholecystokinin/gastrin-mediated Signaling, Complement System, RhoA Signaling, Glycosaminoglycan Degradation, CCR3 Signaling in Eosinophils, Selenoamino Acid Metabolism, Semaphorin Signaling in Neurons, Acute Phase Response Signaling, Ephrin Receptor Signaling, Chemokine Signaling, Leukocyte Extravasation Signaling, VEGF Signaling, Thrombin Signaling
8 AIRE, C15ORF63, Ca2+, CTSD, D-glucose, DAPK3, EEF2, ganglioside GM3, GBA2, GH1, GHR, GLYCOGEN PHOSPHORYLASE, GPR1, GRB2, heparin, HTT, LTF, MCHR2, MYL2, MYO3B, NISCH, P2RX7, PFN2, PKC ALPHA/BETA, PLA2G12A, PLA2G2D, Pld, PPA2, PPP1R12A, PPP1R1A, PPP3CA, PRF1, SELL, SLC7A9, SORBS1 16 11 Cell Signaling, Molecular Transport, Vitamin and Mineral Metabolism Primary Immunodeficiency Signaling, Starch and Sucrose Metabolism, Atherosclerosis Signaling, Oxidative Phosphorylation, Eicosanoid Signaling, Cyanoamino Acid Metabolism, Stillbene, Coumanine and Lignin Biosynthesis, Phospholipid Degradation, Endothelin-1 Signaling, p38 MAPK signaling, MIF Regulation of Innate Immunity, CCR3 Signaling in Eosinophils, Arachidonic Acid Metabolism, Glycerophospholipid Metabolism, Linoleic Acid Metabolism
9 ARRB2, beta-estradiol, CCL5, CCL13, CCR5, Creatine Kinase, CSNK1A1L, EEF2, EIF2AK2, FOXO1, GAR1, HSP90AB1, KPNB1, KRI1, LAGE3, NHP2, OSGEP, OTUD5, PCNA, PPM1K, RAF1, RAN, RANGRF, RPLP0 (includes EG:6175), RPS6, SNRPE, SPN, SPRY2, SPRYD5, TACR1, TGFBR2, TNFRSF1B, TRAF3, XPO1, XPO5 16 11 Cell Death, Cell-mediated Immune Response, Cellular Movement Leukocyte Extravasation Signaling
10 ALPHA AMYLASE, AMY1A, AMY1B, BMP8B, CD44, CSF1, DAG1, DNAH6, DYNLT1, EPO, FOXO1, FOXO3, FYN, glycogen, GRIN1, HCLS1, IL15, INPPL1, KCNH6, LCK, LMOD3, MIR9-1 (includes EG:407046), NMT1, oleic acid, PLCG2, Pld, PLIN5, RPS4Y2, Shc, SHC1, SHCBP1, TDRD1, VCAM1, VEGF 15 11 Cellular Development, Cell Cycle, Cell Death Starch and Sucrose Metabolism, Factor Promoting Cardiogenesis in Vertebrates, Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency, Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis, Basal Cell Carcinoma Signaling, BMP Signaling
11 ASB1, BEGAIN, C1ORF9, C8ORF45, CCDC85B, CTSD, DEFB103A, Eotaxin, EREG, ganglioside GD1a, ganglioside GD1b, ganglioside GM1, ganglioside GM2, ganglioside GM3, ganglioside GT1, GHR, IL32, KIAA0408, LHX4, MAFF, MAPK1, MIR202 (includes EG:387198), NDUFA5, NEUROG3, NRP1, PCBP2, PDE4C, PSAP, ROBO1, SEMA3D, SEMA3E, Sphk, TNF, ZFP36, ZNF337 14 12 Lipid Metabolism, Small Molecule Biochemistry, Cell Morphology Purine Metabolism, Aminosugars Metabolism, Oxidative Phosphorylation, Lipid Antigen Presentation by CD1, Axonal Guidance Signaling, Ubiquinone Biosynthesis
12 ACTN1, BCAS2, C16ORF72, COPS2, CTTNBP2, CTTNBP2NL, DNTTIP2, EGR1, ESR1, ESR2, FAM40A, FAM40B, FAM63B, G alphai, JUN, MCC, MCM2, MIR122, MIR214 (includes EG:406996), MOBKL3, NR0B1, NR2F1, NRIP1, PPP2R1A, PTEN, retinoic acid, RNF122, RP6-213H19.1, SIKE1, STK24, STK25, STRN, STRN3, TRAF3IP3 9 7 Gene Expression, Cellular Development, Cellular Growth and Proliferation Oxidative Phosphorylation