Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers

BMC Medical Genomics

Table 2 Human small airway epithelium MUC5AC-associated core genes ^1,2

Mucus components	Mucin producing cell differentiation-related		Post-translational modification of mucin	Vesicle transport	Endoplasmic reticulum stress-associated	Secretory granule- associated	Mucus secretion-related regulators	Mucus hypersecretory- related ion channels
Mucus components	Transcription factors	Pathways or meditators	Post-translational modification of mucin	Vesicle transport	Endoplasmic reticulum stress-associated	Secretory granule- associated	Mucus secretion-related regulators	Mucus hypersecretory- related ion channels
TFF3	SPDEF	HES1	AGR2	MIA3	CREB3L1	SYTL2	PRSS23	SLC12A2
TFF1	FOXA3	TSTA3	GNE	SURF4	EDEM3	RAB3D	PLCE1	CLCA2
	SOX2	LRRFIP2	GALNT4	KDELR2	XBP1	SCIN	DGKA	SCNN1A
	KLF4	KRAS	GALNT7	KDELR3	EIF2AK3	STXBP6	ITPR3	GABRP
		MAPK13	GALNT12	ITSN1		RAB27B	PRKCD
		RPS6KA3	PDIA5	ERGIC1		SYTL4
		CTSC	FUT3	CKAP4		SYTL5
		SERPINB4	FUT6	GOSR1		GSN
		PLA2G4A	ST6GAL1	SYNJ2BP		RIMS1
			ST8SIA1	MPPE1		CASK
			CHST6	SEC31A		MYO5B
			GALNT5	ARF4		MYO5C
			GALNT6	VPS13D		PCLO
				SEC22B		PAM
				TPD52		ATP6V0A4 KIF5B CDC42EP5

¹ Genes with a role in mucus production or mucus secretion (based on the literature) were selected from the significantly up-regulated genes in nonsmoker high-MUC5AC expressors compared to nonsmoker low-MUC5AC expressors (see Supplemental Methods for complete criteria).
² References for the functions of each gene are in Additional file 1: Table S1. See Additional file 1: Figure S1, S2 for the schematic illustration of the functions of these genes relevant to MUC5AC-production/secretion.

ISSN: 1755-8794