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Table 2 Human small airway epithelium MUC5AC-associated core genes 1,2

From: Genes associated with MUC5AC expression in small airway epithelium of human smokers and non-smokers

Mucus components Mucin producing cell differentiation-related Post-translational modification of mucin Vesicle transport Endoplasmic reticulum stress-associated Secretory granule- associated Mucus secretion-related regulators Mucus hypersecretory- related ion channels
Transcription factors Pathways or meditators
TFF3 SPDEF HES1 AGR2 MIA3 CREB3L1 SYTL2 PRSS23 SLC12A2
TFF1 FOXA3 TSTA3 GNE SURF4 EDEM3 RAB3D PLCE1 CLCA2
  SOX2 LRRFIP2 GALNT4 KDELR2 XBP1 SCIN DGKA SCNN1A
  KLF4 KRAS GALNT7 KDELR3 EIF2AK3 STXBP6 ITPR3 GABRP
   MAPK13 GALNT12 ITSN1   RAB27B PRKCD  
   RPS6KA3 PDIA5 ERGIC1   SYTL4   
   CTSC FUT3 CKAP4   SYTL5   
   SERPINB4 FUT6 GOSR1   GSN   
   PLA2G4A ST6GAL1 SYNJ2BP   RIMS1   
    ST8SIA1 MPPE1   CASK   
    CHST6 SEC31A   MYO5B   
    GALNT5 ARF4   MYO5C   
    GALNT6 VPS13D   PCLO   
     SEC22B   PAM   
     TPD52   ATP6V0A4
KIF5B
CDC42EP5
  
  1. 1 Genes with a role in mucus production or mucus secretion (based on the literature) were selected from the significantly up-regulated genes in nonsmoker high-MUC5AC expressors compared to nonsmoker low-MUC5AC expressors (see Supplemental Methods for complete criteria).
  2. 2 References for the functions of each gene are in Additional file 1: Table S1. See Additional file 1: Figure S1, S2 for the schematic illustration of the functions of these genes relevant to MUC5AC-production/secretion.