Table 1 Baseline data for used AC cohorts
From: Relation between smoking history and gene expression profiles in lung adenocarcinomas
Illumina | DCC | GSE10072 | GSE12667 | Beer et al. | GSE32863 | GSE11969 | |
|---|---|---|---|---|---|---|---|
Data set type | Original cohort | External | External | External | External | External | External |
Microarray platform | Illumina HT12 | Affymetrix U133A | Affymetrix U133A | Affymetrix U133 2plus | Affymetrix HU6800 | Illumina WG6 | Agilent |
Number of AC cases* | 39*** | 349 | 58 | 51 | 81 | 58 | 90 |
Stage IA/IB/IIA/IIB/IIIA | 10/18/4/3/2 | 84/133/16/64/45 | 5/17/3/18/9 | 2/9/0/2/2 | NA | 16/18/9/2/12 | 28/24/4/9/20 |
Median age (years) | 69 (36–83) | 65 (35–87) | 67.5 (45–81) | NA | 64 (41–85) | 70 (39–86) | 62 (32–84) |
Female/Male | 21/18 | 187/162 | 23/35 | 24/27 | 47/34 | 45/13 | 43/47 |
Never-smokers/Smokers | 10/27 | 49/300 | 16/42 | 8/43 | 9/72 | 29/29 | 45/45 |
Never/Current/Former smokers | 10/13/14 | 49/32/268 | 16/24/18 | 8/18/25 | 9/NA/NA | 29/29/0 | 45/NA/NA |
Percentage never-smokers | 27% | 14% | 28% | 16% | 11% | 50% | 50% |
Never-smokers (Female/Male) | 6/4 | 40/9 | 13/3 | 6/2 | 9/0 | 23/6 | 35/10 |
EGFR mutation/wt | 4/35 | NA | NA | NA | NA | NA | 32/58 |
KRAS mutation/wt | 12/27 | NA | NA | NA | 36/44 | NA | 10/80 |
P53 +/wt | NA | NA | NA | NA | 16/64 | NA | 29/61 |
Mean follow-up OS (years)** | 6.2 (0–15.5) | 4.3 (0–17) | NA | NA | 3 (0.1–9.2) | NA | 5.5 (0.5–9) |