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Table 1 Baseline data for used AC cohorts

From: Relation between smoking history and gene expression profiles in lung adenocarcinomas

  Illumina DCC GSE10072 GSE12667 Beer et al. GSE32863 GSE11969
Data set type Original cohort External External External External External External
Microarray platform Illumina HT12 Affymetrix U133A Affymetrix U133A Affymetrix U133 2plus Affymetrix HU6800 Illumina WG6 Agilent
Number of AC cases* 39*** 349 58 51 81 58 90
Stage IA/IB/IIA/IIB/IIIA 10/18/4/3/2 84/133/16/64/45 5/17/3/18/9 2/9/0/2/2 NA 16/18/9/2/12 28/24/4/9/20
Median age (years) 69 (36–83) 65 (35–87) 67.5 (45–81) NA 64 (41–85) 70 (39–86) 62 (32–84)
Female/Male 21/18 187/162 23/35 24/27 47/34 45/13 43/47
Never-smokers/Smokers 10/27 49/300 16/42 8/43 9/72 29/29 45/45
Never/Current/Former smokers 10/13/14 49/32/268 16/24/18 8/18/25 9/NA/NA 29/29/0 45/NA/NA
Percentage never-smokers 27% 14% 28% 16% 11% 50% 50%
Never-smokers (Female/Male) 6/4 40/9 13/3 6/2 9/0 23/6 35/10
EGFR mutation/wt 4/35 NA NA NA NA NA 32/58
KRAS mutation/wt 12/27 NA NA NA 36/44 NA 10/80
P53 +/wt NA NA NA NA 16/64 NA 29/61
Mean follow-up OS (years)** 6.2 (0–15.5) 4.3 (0–17) NA NA 3 (0.1–9.2) NA 5.5 (0.5–9)
  1. * Number of cases with smoking history.
  2. ** OS: Overall survival.
  3. ***: Two cases are not annotated for smoking.