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Table 3 GO categories overrepresented in the gene set DEG_wBC (time point 0 hours) top-ranked with b) or without BC a)

From: Batch correction of microarray data substantially improves the identification of genes differentially expressed in Rheumatoid Arthritis and Osteoarthritis

TermID

Members (DEG/all)

P-value

Category

a)

GO:0005201

3/74

5.87e-03

extracellular matrix structural constituent

GO:0050840

2/26

6.62e-03

extracellular matrix binding

GO:0005100

2/28

7.65e-02

Rho GTPase activator activity

GO:0008307

2/40

1.52e-02

structural constituent of muscle

GO:0005178

2/57

2.96e-02

integrin binding

GO:0001871

3/154

3.61e-02

pattern binding

GO:0030246

3/156

3.70e-02

carbohydrate binding

b)

GO:0005201

8/74

7.60E-07

extracellular matrix structural constituent

GO:0048407

4/11

3.29E-06

platelet-derived growth factor binding

GO:0005540

3/19

9.04E-04

hyaluronic acid binding

GO:0015355

2/5

1.02E-03

secondary active monocarboxylate transmembrane transporter activity

GO:0004035

2/6

1.52E-03

alkaline phosphatase activity

GO:0005178

4/57

2.74E-03

integrin binding

GO:0004000

2/9

3.58E-03

adenosine deaminase activity

GO:0050840

2/26

7.46E-03

extracellular matrix binding

GO:0008307

3/40

7.88E-03

structural constituent of muscle

GO:0046332

3/42

9.02E-03

SMAD binding

GO:0030674

3/44

1.02E-02

protein binding

GO:0016853

4/83

1.02E-02

isomerase activity

GO:0000287

10/441

1.53E-02

magnesium ion binding

GO:0005507

3/62

2.56E-02

copper ion binding

GO:0042802

7/289

3.17E-02

identical protein binding

GO:0005100

2/28

3.31E-02

Rho GTPase activator activity

GO:0005518

2/31

3.94E-02

collagen binding

GO:0016903

2/33

4.47E-02

oxidoreductase activity

  1. GO categories overrepresented in both data sets are highlighted in bold. Please note that both the number of the category members and the p-values for differential expression considerably improve by BC.