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Table 2 Highly Significant Alternatively Spliced Genes

From: A systematic comparison and evaluation of high density exon arrays and RNA-seq technology used to unravel the peripheral blood transcriptome of sickle cell disease

Symbol

GeneTitle

Molecular Functions

RNAseq

MA

   

Splicing Index

ATF6B*

activating transcription factor 6 beta

Cell Death/Immune Response

0.49*

0.17

BCL6*

B-cell CLL

Apoptosis/Immune Response

0.68*

0.07

CARM*

coactivator-associated arginine methyltransferase 1

Cell Development/Differentiation

0.40*

0.12

CCND*

cyclin D-type binding-protein 1

Cell Cycle

0.63*

0.13

COX4I*

cytochrome c oxidase subunit IV iso1

Cellular Development/Compromise

0.89*

0.04

DCTN*

dynactin 2 (p50)

Cellular Movement

0.47*

0.08

HPS1*

Hermansky-Pudlak syndrome 1

Inflammatory Response; Cell Signaling

0.39*

0.15

INPP5*

inositol polyphosphate-5-phosphatase

Cell-Cell Signaling

0.49*

0.07

INSIG1*

insulin induced gene 1

Lipid metabolism, Molecular Transport

0.52*

0.09

NUDT*

nudix type motif 4

Cell signaling; Hematopoiesis

0.37*

0.16

NUDT*

nudix motif 4 pseudogene

Cell signaling; Hematopoiesis

0.37*

0.16

RHCE*

Rh blood group, CcEe antigens

Agglutination of red blood cells

0.54*

0.18

RHD*

Rh blood group, D antigen

Agglutination of red blood cells

0.54*

0.18

TNXA*

tenascin XA (pseudogene)

Cellular Assembly

0.49*

0.17

TNXB*

tenascin XB

Cellular Assembly

0.49*

0.17

UNC13*

unc-13 homolog D

Cell Signaling

0.76*

0.10

HBA1**

hemoglobin, alpha 1

Transport of oxygen

0.09

0.57**

  1. * Selected genes from RNA-Seq with P < 0.00000001.
  2. ** Selected Genes from Microarray with P < 0.00000001.
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BMC Medical Genomics

ISSN: 1755-8794

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