TY - JOUR AU - Wang, Danxin AU - Curtis, Amanda AU - Papp, Audrey C. AU - Koletar, Susan L. AU - Para, Michael F. PY - 2012 DA - 2012/07/23 TI - Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients JO - BMC Medical Genomics SP - 32 VL - 5 IS - 1 AB - Sulfamethoxazole (SMX) is a commonly used antibiotic for prevention of infectious diseases associated with HIV/AIDS and immune-compromised states. SMX-induced hypersensitivity is an idiosyncratic cutaneous drug reaction with genetic components. Here, we tested association of candidate genes involved in SMX bioactivation and antioxidant defense with SMX-induced hypersensitivity. SN - 1755-8794 UR - https://doi.org/10.1186/1755-8794-5-32 DO - 10.1186/1755-8794-5-32 ID - Wang2012 ER -