Figure 5
Genes differentially expressed after miR-7 or miR-128 transfection display distinct pathway signatures. The majority of pathways enriched (FDR <0.05) among (A) differentially expressed genes after miR-7 transfection, (B) differentially expressed genes after miR-128 transfection are related to development. Cell cycle, cytoskeleton remodeling, apoptosis and signal transduction pathways are also enriched and may signify cancer specific processes. Distribution of groups of pathways enriched among (C) down-regulated genes after miR-7 transfection or (D) down-regulated genes after miR-128 transfection indicate that pathways involved in development are the largest fraction of enriched pathways for miR-7 while genes down-regulated by miR-128 are enriched for pathways involved in cell cycle regulation revealing a distinct pathway signature for each miRNA.