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Table 2 Twenty most significantly enriched (FDR < 0.05) GeneGo pathways among differentially expressed genes after miR-7 (A) or miR-128 (B) transfection into HEY cells

From: The effects of MicroRNA transfections on global patterns of gene expression in ovarian cancer cells are functionally coordinated

A.
Pathways enriched among miR-7 modulated genes p-value
Cell adhesion_Chemokines and adhesion 1.31E-07
Cell cycle_Regulation of G1/S transition (part 1) 8.68E-07
Cell adhesion_Ephrin signaling 3.96E-06
Development_EGFR signaling pathway 1.02E-05
Development_ERBB-family signaling 1.13E-05
Development_WNT signaling pathway. Part 1. Degradation of beta-catenin in the absence WNT signaling 1.42E-05
Development_VEGF-family signaling 1.68E-05
Cytoskeleton remodeling_Cytoskeleton remodeling 3.13E-05
Neurophysiological process_Receptor-mediated axon growth repulsion 3.43E-05
Proteolysis_Putative ubiquitin pathway 3.44E-05
Development_TGF-beta-dependent induction of EMT via RhoA, PI3K and ILK. 4.05E-05
Cell adhesion_Plasmin signaling 4.85E-05
Development_TGF-beta-dependent induction of EMT via SMADs 4.85E-05
Transport_RAB5A regulation pathway 5.75E-05
Cytoskeleton remodeling_TGF, WNT and cytoskeletal remodeling 7.29E-05
Cell cycle_Regulation of G1/S transition (part 2) 7.30E-05
Apoptosis and survival_HTR1A signaling 7.54E-05
Development_Regulation of epithelial-to-mesenchymal transition (EMT) 7.67E-05
Translation _Regulation of EIF2 activity 1.01E-04
Cell adhesion_ECM remodeling 1.01E-04
B.
Pathways enriched among miR-128 modulated genes p-value
Cell cycle_The metaphase checkpoint 1.01E-11
Cytoskeleton remodeling_TGF, WNT and cytoskeletal remodeling 1.29E-09
Cell cycle_Role of Nek in cell cycle regulation 1.77E-09
Transport_Clathrin-coated vesicle cycle 4.15E-09
Cell cycle_Initiation of mitosis 4.37E-09
Immune response_Histamine H1 receptor signaling in immune response 1.78E-07
Cell cycle_Role of APC in cell cycle regulation 1.79E-07
Cell cycle_Spindle assembly and chromosome separation 2.75E-07
Cytoskeleton remodeling_Cytoskeleton remodeling 2.98E-07
Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway 3.68E-07
Cytoskeleton remodeling_Neurofilaments 6.14E-07
Cell cycle_Chromosome condensation in prometaphase 8.18E-07
Immune response_Gastrin in inflammatory response 1.85E-06
Neurophysiological process_Receptor-mediated axon growth repulsion 2.69E-06
Translation_Non-genomic (rapid) action of Androgen Receptor 3.55E-06
Development_PIP3 signaling in cardiac myocytes 4.80E-06
Cytoskeleton remodeling_Role of Activin A in cytoskeleton remodeling 5.34E-06
Apoptosis and survival_Apoptotic Activin A signaling 5.76E-06
Apoptosis and survival_BAD phosphorylation 6.54E-06
Immune response_Fc epsilon RI pathway 7.40E-06
  1. The pathways that are enriched among differentially expressed genes after both miR-7 and miR-128 transfection are highlighted in bold.