Table 2 Twenty most significantly enriched (FDR < 0.05) GeneGo pathways among differentially expressed genes after miR-7 (A) or miR-128 (B) transfection into HEY cells

Cell adhesion_Chemokines and adhesion

1.31E-07

Cell cycle_Regulation of G1/S transition (part 1)

8.68E-07

Cell adhesion_Ephrin signaling

3.96E-06

Development_EGFR signaling pathway

1.02E-05

Development_ERBB-family signaling

1.13E-05

Development_WNT signaling pathway. Part 1. Degradation of beta-catenin in the absence WNT signaling

1.42E-05

Development_VEGF-family signaling

1.68E-05

Cytoskeleton remodeling_Cytoskeleton remodeling

3.13E-05

Neurophysiological process_Receptor-mediated axon growth repulsion

3.43E-05

Proteolysis_Putative ubiquitin pathway

3.44E-05

Development_TGF-beta-dependent induction of EMT via RhoA, PI3K and ILK.

4.05E-05

Cell adhesion_Plasmin signaling

4.85E-05

Development_TGF-beta-dependent induction of EMT via SMADs

4.85E-05

Transport_RAB5A regulation pathway

5.75E-05

Cytoskeleton remodeling_TGF, WNT and cytoskeletal remodeling

7.29E-05

Cell cycle_Regulation of G1/S transition (part 2)

7.30E-05

Apoptosis and survival_HTR1A signaling

7.54E-05

Development_Regulation of epithelial-to-mesenchymal transition (EMT)

7.67E-05

Translation _Regulation of EIF2 activity

1.01E-04

Cell adhesion_ECM remodeling

1.01E-04

B.

Pathways enriched among miR-128 modulated genes

p-value

Cell cycle_The metaphase checkpoint

1.01E-11

Cytoskeleton remodeling_TGF, WNT and cytoskeletal remodeling

1.29E-09

Cell cycle_Role of Nek in cell cycle regulation

1.77E-09

Transport_Clathrin-coated vesicle cycle

4.15E-09

Cell cycle_Initiation of mitosis

4.37E-09

Immune response_Histamine H1 receptor signaling in immune response

1.78E-07

Cell cycle_Role of APC in cell cycle regulation

1.79E-07

Cell cycle_Spindle assembly and chromosome separation

2.75E-07

Cytoskeleton remodeling_Cytoskeleton remodeling

2.98E-07

Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway

3.68E-07

Cytoskeleton remodeling_Neurofilaments

6.14E-07

Cell cycle_Chromosome condensation in prometaphase

8.18E-07

Immune response_Gastrin in inflammatory response

1.85E-06

Neurophysiological process_Receptor-mediated axon growth repulsion

2.69E-06

Translation_Non-genomic (rapid) action of Androgen Receptor

3.55E-06

Development_PIP3 signaling in cardiac myocytes

4.80E-06

Cytoskeleton remodeling_Role of Activin A in cytoskeleton remodeling

5.34E-06

Apoptosis and survival_Apoptotic Activin A signaling

5.76E-06

Apoptosis and survival_BAD phosphorylation

6.54E-06

Immune response_Fc epsilon RI pathway

7.40E-06