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Table 2 Concordance of functional annotation cluster (using DAVID®) with the four clusters identified based on differential gene expression

From: Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell lines

Description Cluster 1 Cluster 2 Cluster 3 Cluster 4
Number of genes     
Total 1378 2005 428 642
Identified as human by DAVID 1332 1932 416 617
Mapped by DAVID with GO terms 1187 (86.1%) 1704 (85.0%) 380 (88.8%) 532 (82.9%)
Functional cluster rank (enrichment score*)     
1 Mitochondria Mitosis Vacuole Anti-apoptosis
(12.08) (24.40) (10.18) (2.72)
2 Ribosomes Kinetochore Endocytosis Kinase binding
(7.72) (16.34) (2.82) (2.67)
3 Catabolism Intracellular organelle Cell fraction Apoptosis regulation
(6.53) (12.53) (2.56) (2.59)
4 Intracellular organelle DNA Replication Metal ion binding Intracellular organelle
(4.80) (11.96) (2.37) (2.25)
5 Ubiquitination DNA Repair Lysosome Metal ion binding
  (4.10) (11.85) (1.86) (2.05) and
     Tyrosine kinase activity
     (2.05)
  1. DAVID Database for Annotation, Visualization and Integrated Discovery; GO gene ontology. enrichment scores are the average –log10 p-values for the genes loading onto the specified functional cluster.