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Table 3 Annotation of the 34 genes that were differentially expressed upon treatment as well as associated with SDR

From: Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell lines

Probe ID

Gene symbol

Gene name

Cluster

iFC

oFC

Pathways

ILMN_1691364

STAT1

Signal transducer and activator of transcription 1, 91 kDa

1

−0.1071

0.2270

IFNα/ß/Γ; oncostatin M, Thrombopoetin; Angiopoetin, PDGF; IL-1/IL-9/IL-22;/IL23; EGFR; p53; SUMO-1; Leptin

ILMN_1700028

C9orf156

Chromosome 9 open reading frame 156

1

−0.0526

0.2686

 

ILMN_1747771

MAEA

Macrophage erythroblast attacher

1

−0.0370

0.2202

 

ILMN_1751803

LSM10

LSM10, U7 small nuclear RNA associated

1

−0.0924

0.1841

 

ILMN_1770892

YY1

YY1 transcription factor

1

0.0556

0.2401

TGF-ß signaling, NOTCH signaling, p53 signaling

ILMN_2258268

GLRX2

Glutaredoxin 2

1

−0.1088

0.2979

 

ILMN_2309228

GPS1

G protein pathway suppressor 1

1

0.0364

0.3378

 

ILMN_1659753

LAMP2

Lysosomal-associated membrane protein 2

2

0.0400

−0.2695

 

ILMN_1677691

GP2

Glycoprotein 2 (zymogen granule membrane)

2

0.0012

−0.3267

Integrin inside-out signaling

ILMN_1682775

EDN1

Endothelin 1

2

−0.5040

−0.4670

Leptin signaling via JAK/STAT & MAPK, EGFR transactivation, IL-1 signaling, EDRNA signaling

ILMN_1695058

SLC38A5

Solute carrier family 38, member 5

2

−0.1257

−0.2268

 

ILMN_1703906

HJURP

Holliday junction recognition protein

2

−0.0682

−0.6162

 

ILMN_1707591

TNIP3

TNFAIP3 interacting protein 3

2

−0.3585

−0.5433

 

ILMN_1713952

C1orf106

Chromosome 1 open reading frame 106

2

−0.0368

−0.3012

 

ILMN_1732516

KNTC1

Kinetochore associated 1

2

−0.0216

−0.3534

Spindle assembly

ILMN_1769545

PRPF19

PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)

2

−0.0770

−0.3237

NOTCH signaling

ILMN_1774077

GBP2

Guanylate binding protein 2, interferon-inducible

2

−0.0388

−0.4636

 

ILMN_1849494

EFR3B

EFR3 homolog B (S. cerevisiae)

2

−0.0256

−0.4698

 

ILMN_1868655

AI916641

 

2

−0.1451

−0.4635

 

ILMN_1898692

BI254341

 

2

−0.2912

−0.3491

 

ILMN_1912827

CB157495

 

2

−0.1382

−0.5097

 

ILMN_2103685

DEPDC1B

DEP domain containing 1B

2

−0.1807

−0.7007

 

ILMN_2230162

FLJ44124

Hypothetical LOC641737

2

0.0233

−0.3135

 

ILMN_2336595

ACSS2

Acyl-CoA synthetase short-chain family member 2

2

0.1570

−0.5157

 

ILMN_2384544

ADAM15

ADAM metallopeptidase domain 15

2

0.2186

−0.3365

 

ILMN_1677200

CYFIP2

Cytoplasmic FMR1 interacting protein 2

3

0.3287

−0.2998

G-protein signaling RAC1

ILMN_1724437

GCAT

Glycine C-acetyltransferase (2-amino-3- ketobutyrate coenzyme A ligase)

3

0.2763

−0.1991

 

ILMN_1789436

AK091207

 

3

0.4950

0.2848

 

ILMN_2392352

CTPS2

CTP synthase II

3

0.1718

0.0349

 

ILMN_1664798

GRHPR

Glyoxylate reductase/hydroxypyruvate reductase

4

0.1026

0.4346

 

ILMN_1693338

CYP1B1

Cytochrome P450, family 1, subfamily B, polypeptide 1

4

0.1427

0.4242

Benzopyrene, estradiol and retinol metabolism

ILMN_1764361

DUSP16

Dual specificity phosphatase 16

4

0.2176

0.6187

p53; Erk

ILMN_1779428

C12orf68

Chromosome 12 open reading frame 68

4

0.0770

0.3965

 

ILMN_1794956

BBS9

Bardet-Biedl syndrome 9

4

0.1743

0.5875