Table 3 Canonical pathways upregulated in Her2+ compared to ER + and TNBC samples
From: Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles
Enriched ingenuity canonical pathways | pval | # of genes | Genes | |||
|---|---|---|---|---|---|---|
P | L | ↑ | ↓ |  | ||
Actin Cytoskeleton Signaling | 0.0002 | 226 | 20 | 20 | 0 | PFN1↑, MYL6↑, CFL1↑, ARPC5L↑, CSK↑, HRAS↑, ITGA5↑, IQGAP1↑, ITGA3↑, BCAR1↑, ACTG1↑, MYL9↑, MYL12A↑, PIP5K1C↑, ARPC2↑, RHOA↑, MYH9↑, VCL↑, ACTN1↑, MSN↑ |
Integrin Signaling | 0.0008 | 205 | 18 | 18 | 0 | MAP3K11↑, RHOC↑, ARPC5L↑, ILK↑, HRAS↑, PLCG1↑, ITGA5↑, TNK2↑, ITGA3↑, BCAR1↑, ACTG1↑, NCK2↑, ARF1↑, MYL12A↑, ARPC2↑, RHOA↑, VCL↑, ACTN1↑ |
Regulation of Actin-based Motility by Rho | 0.001 | 87 | 11 | 11 | 0 | MYL9↑, MYL12A↑, PFN1↑, CFL1↑, MYL6↑, ARPC5L↑, PIP5K1C↑, RHOC↑, ARPC2↑, RHOA↑, ARHGDIA↑ |
Rac Signaling | 0.002 | 117 | 12 | 12 | 0 | RELA↑, MAP3K11↑, CFL1↑, ARPC5L↑, PIP5K1C↑, ARPC2↑, RHOA↑, ITGA5↑, HRAS↑, SH3RF1↑, ITGA3↑, IQGAP1↑ |
Cdc42 Signaling | 0.003 | 142 | 13 | 13 | 0 | MPRIP↑, MAP3K11↑, CFL1↑, MYL6↑, ARPC5L↑, ITGA5↑, TNK2↑, ITGA3↑, IQGAP1↑, HLA-F↑, MYL9↑, MYL12A↑, ARPC2↑ |
ILK Signaling | 0.005 | 182 | 15 | 14 | 1 | RELA↑, CFL1↑, MYL6↑, RHOC↑, ILK↑, ACTG1↑, MYC↓, NCK2↑, MYL9↑, TGFB1I1↑, PPP2R1A↑, FLNA↑, RHOA↑, MYH9↑, ACTN1↑ |
RhoA Signaling | 0.006 | 107 | 11 | 11 | 0 | MYL9↑, MYL12A↑, PFN1↑, CFL1↑, MYL6↑, ARPC5L↑, PIP5K1C↑, ARPC2↑, RHOA↑, ACTG1↑, MSN↑ |
PI3K/AKT Signaling | 0.010 | 129 | 11 | 10 | 1 | RELA↑, PPP2R1A↑, NFKBIA↓, YWHAH↑, TSC2↑, TYK2↑, ILK↑, ITGA5↑, HRAS↑, ITGA3↑, NFKBIB↑ |
Germ Cell-Sertoli Cell Junction Signaling | 0.010 | 159 | 13 | 13 | 0 | MAP3K11↑, RHOC↑, TUBB2A↑, ILK↑, HRAS↑, ITGA3↑, IQGAP1↑, BCAR1↑, ACTG1↑, TUBB6↑, SORBS1↑, RHOA↑, ACTN1↑ |
Cardiac Hypertrophy Signaling | 0.010 | 228 | 16 | 14 | 1 | MAP3K11↑, CALM1↑, MYL6↑, RHOC↑, PLCG1↑, HRAS↑, PPP3CC↑, EIF2B2↑, MYL9↑, GNB1↑, PLCD3↓, MYL12A↑, PLCB4↑, RHOA↑, MAPKAPK2↑, HSPB1↑ |
Phospholipase C Signaling | 0.01 | 243 | 16 | 14 | 0 | RELA↑, MYL6↑, CALM1↑, RHOC↑, PLCG1↑, ITGA5↑, PPP1R14A↑, HRAS↑, ARHGEF17↑, PPP3CC↑, ITGA3↑, MYL9↑, GNB1↑, PLCB4↑, MYL12A↑, RHOA↑ |
Protein Kinase A Signaling | 0.01 | 306 | 19 | 13 | 3 | RELA↑, YWHAH↑, MYL6↑, CALM1↑, PPP1R14A↑, PLCG1↑, PPP1R11↑, PPP3CC↑, MYL9↑, GNB1↑, PLCD3↓, MYL12A↑, PLCB4↑, NFKBIA↓, PDE7B↓, FLNA↑, RHOA↑, NFKBIB↑, PDE6D↑ |
FAK Signaling | 0.01 | 98 | 9 | 9 | 0 | CSK↑, PLCG1↑, ITGA5↑, HRAS↑, VCL↑, ITGA3↑, TNS1↑, BCAR1↑, ACTG1↑ |
fMLP Signaling in Neutrophils | 0.01 | 117 | 10 | 6 | 0 | GNB1↑, RELA↑, PLCB4↑, NFKBIA↓, CALM1↑, ARPC5L↑, ARPC2↑, HRAS↑, PPP3CC↑, NFKBIB↑ |
Axonal Guidance Signaling | 0.04 | 422 | 21 | 21 | 0 | KLC1↑, PFN1↑, GLI2↑, PLXNA3↑, MYL6↑, CFL1↑, ARPC5L↑, TUBB2A↑, HRAS↑, TGA5↑, PPP3CC↑, ITGA3↑, BCAR1↑, NCK2↑, MYL9↑, GNB1↑, PLCB4↑, MYL12A↑, TUBB6↑, ARPC2↑, RHOA↑ |
Neuregulin Signaling | 0.04 | 95 | 8 | 6 | 2 | MYC↓, PICK1↑, PLCG1↑, ITGA5↑, HBEGF↑, HRAS↑, ITGA3↑, STAT5B↓ |
PAK Signaling | 0.05 | 104 | 8 | 8 | 0 | NCK2↑, MYL9↑, MYL12A↑, CFL1↑, MYL6↑, ITGA5↑, HRAS↑, ITGA3↑ |
Virus Entry via Endocytic Pathways | 0.05 | 92 | 8 | 8 | 0 | AP2M1↑, FLNA↑, PLCG1↑, ITGA5↑, HRAS↑, ITGA3↑, ACTG1↑, DNM2↑ |