Table 1 Characteristic of patients and datasets
From: Immune genes are associated with human glioblastoma pathology and patient survival
Name Dataset origin | de Tayrac GSE4271 GSE4412 | Lee GSE13041 | Verhaak TCGA Data Portal | Petalidis GSE2727 | Local_1 CHU Rennes CHU Angers | Local_2 CHU Rennes | |
|---|---|---|---|---|---|---|---|
Technology Number of samples | Affymetrix | Affymetrix | Affymetrix | Affymetrix | Agilent | Q-PCR | |
115 | 161 | 173 | 39 | 41 | 57 | ||
Gender | Male | M:65 | M:96 | M:112 | M:29 | M:21 | M:31 |
Female | F:50 | F:65 | F:61 | F:10 | F:20 | F:26 | |
Age (y) | median [min-max] | 48 [18-82] | 55 [22-86] | 59 [14-87] | 61 [22-74] | 58 [33-80] | 59 [36-78] |
<50 | 65 | 59 | 56 | 14 | 10 | 10 | |
> = 50 | 50 | 102 | 117 | 25 | 31 | 47 | |
KPS (%) | median | - | - | 90 [40-100] | - | 80 [40-100] | 80 [40-100] |
<=70 | - | - | 22 | - | 15 | 28 | |
>70 | - | - | 58 | - | 23 | 29 | |
NA | - | - | - | 3 | - | ||
Treatment (surgical) | biopsy | - | - | 6 | 1 | 2 | |
partial resection | - | - | - | 8 | 17 | ||
total resection | - | 161(a) | 164 | (c) | 26 | 38 | |
NA | - | - | 1 | 6 | - | ||
Treatment (adjuvant) | RT | - | 3 | - | |||
RT + CT like Stupp’s schedule | - | (b) | (b) | (c) | 37 | 57 | |
no treatment | - | 1 | - | ||||
MGMT status | Methylated | - | 86 | 42 | - | 24 | 27 |
Un-methylated | - | 75 | 122 | - | 17 | 29 | |
NA | - | - | - | - | - | 1 | |
IDH1 status | Wild-type | - | - | 167 | - | 39 | 39 |
Mutated | - | - | 6 | - | 2 | 1 | |
NA | - | - | - | - | - | 17 | |
Subtype | Proneural | - | 41 | 48 | - | 12 | - |
non-Proneural | - | 120 | 125 | - | 29 | - | |