Systematically characterizing and prioritizing chemosensitivity related gene based on Gene Ontology and protein interaction network

Table 2 Degree of CCRG compared with random genes

	mean of CCRG	mean of random genes	fold*	pvalue^#
BIND	9.24444	3.65349	2.53031	0.002
IntAct	22.01515	7.31961	3.0077	<0.001
MINT	9.77358	5.26234	1.85727	0.021
HPRD	26.10526	7.71614	3.3832	<0.001
BioGRID	24.86486	7.03614	3.53388	<0.001
OPHID	43.71429	12.2352	3.57283	<0.001

*fold is the result of mean degree of CCRG divided by that of random genes.
^#1000 random gene sets was selected from network, each randomization kept the number of selected genes same as that of real genes. Then for CCRG, p value was calculated over 1000 randomization.

ISSN: 1755-8794